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TSPYL2 Antibody

  • 货号：
    CSB-PA854994
  • 规格：
    ￥1100
  • 图片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: CSB-PA854994(TSPYL2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

产品详情

  • Uniprot No.：
    Q9H2G4
  • 基因名：
    TSPYL2
  • 别名：
    CASK interacting nucleosome assembly protein antibody; CDA1 antibody; Cell division autoantigen 1 antibody; Cell division autoantigen 1 nucleolar protein antibody; CTCL tumor antigen se20-4 antibody; CTCL-associated antigen se20-4 antibody; Cutaneous T-cell lymphoma-associated antigen se20-4 antibody; DENTT antibody; Differentially-expressed nucleolar TGF-beta1 target protein antibody; HRIHFB2216 antibody; NP79 antibody; Nuclear protein of 79 kDa antibody; Testis-specific Y-encoded-like protein 2 antibody; TSPX antibody; TSPY-like protein 2 antibody; TSPYL2 antibody; TSYL2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human TSPYL2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
  • 基因功能参考文献：
    1. Genome-wide polysome profiling shows that hCINAP selectively modulates cancer-associated translatome to promote malignancy. PMID: 27477389
    2. Aortic CDA1 expression was downregulated approximately 70% within biopsies from human abdominal aortic aneurysms. PMID: 29311219
    3. TSPY and TSPX exert opposing effects on the transactivation functions of AR and AR-Vs important for various physiological and disease processes sensitive to male sex hormone actions, thereby not only affecting the pathogenesis of male-specific prostate cancer but also likely contributing to sex differences in the health and diseases of man. PMID: 28169398
    4. the extent of the duplicated regions in each case encompassing a minimum of three known disease genes TSPYL2, KDM5C and IQSEC2, is reported. PMID: 26059843
    5. homozygous Asp3779Asn and a hemizygous Ile262Met mutations in the LRP2 and TSPYL2 genes, respectively, in a Pakistani family with two boys affected with mild nonsyndromic intellectual disability PMID: 26529358
    6. s demonstrate that human coilin-interacting nuclear ATPase protein (hCINAP) is a novel negative regulator in NF-kappaB signaling by deactivating IkappaB kinase (IKK) complex. PMID: 26089539
    7. TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFbeta signaling activation PMID: 25613376
    8. Atrial fibrillation can result in alterations in atrial structure and architecture that make the atrial myocardium more susceptible to the maintenance of the arrhythmia. PMID: 25142742
    9. The oncogenic events leading to an ectopic activation of TSPY and/or inactivating mutation/epigenetic silencing of TSPX could collectively contribute to the sexual dimorphism(s) in HCC and related liver cancers in male-biased manners. PMID: 25017435
    10. More importantly, RPS14 was specifically modified with NEDD8 and hCINAP inhibited RPS14 NEDDylation by recruiting NEDD8-specific protease 1 PMID: 23246961
    11. hCINAP may not simply regulate nucleotide homeostasis, but may have broader functionality, including control of Cajal body assembly and disassembly PMID: 22038794
    12. TSPX is principally expressed in Sertoli cells in the human testis. PMID: 21204751
    13. knockdown of CINAP expression results in marked reduction of histone transcription, lower levels of U small nuclear RNAs (U1, U2, U4, and U5), and a loss of cell viability PMID: 20186459
    14. hCINAP is a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus PMID: 16079131
    15. Overexpression of cell division autoantigen-1 (CDA1) slowed parasite growth and induced expression of bradyzoite-specific proteins. Results showed that changes in host cell transcription can influence the molecular environment for bradyzoite development. PMID: 17069459
    16. CDA1 induces p53- and MEK/ERK1/2 MAPK-dependent expression of p21 by acting through the p53 responsive element in the p21 promoter and this contributes to its antiproliferative activity PMID: 17317670
    17. a role for DENTT as a suppressor of the tumorigenic phenotype. PMID: 18381359
    18. This paper characterizes monkey DENTT cDNA and makes a comparison with human and mouse DENTT PMID: 15823505

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Nucleosome assembly protein (NAP) family
  • 组织特异性：
    Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
  • 数据库链接：

    HGNC: 24358

    OMIM: 300564

    KEGG: hsa:64061

    STRING: 9606.ENSP00000364591

    UniGene: Hs.136164