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TSEN2 Antibody

  • 货号：
    CSB-PA850858DSR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TSEN2 antibody at 5μg/ml + 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 54, 52, 50, 48, 46 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA850858DSR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TSEN2 Polyclonal antibody
  • Uniprot No.：
    Q8NCE0
  • 基因名：
    TSEN2
  • 别名：
    HsSen2 antibody; MGC2776 antibody; MGC4440 antibody; SEN2 antibody; SEN2_HUMAN antibody; SEN2L antibody; tRNA intron endonuclease Sen2 antibody; tRNA splicing endonuclease 2 homolog (SEN2; S. cerevisiae) antibody; tRNA splicing endonuclease subunit Sen2 antibody; tRNA-intron endonuclease sen2 antibody; tRNA-splicing endonuclease subunit Sen2 antibody; TSEN 2 antibody; TSEN2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human tRNA-splicing endonuclease subunit Sen2 protein (1-220AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
  • 相关疾病：
    Pontocerebellar hypoplasia 2B (PCH2B)
  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.
  • 蛋白家族：
    TRNA-intron endonuclease family
  • 组织特异性：
    Isoform 1 and isoform 2 are widely expressed at very low level.
  • 数据库链接：

    HGNC: 28422

    OMIM: 608753

    KEGG: hsa:80746

    STRING: 9606.ENSP00000284995

    UniGene: Hs.335550