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TRPV2 Antibody

  • 货号：
    CSB-PA897571LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse skeletal muscle tissue
      All lanes: TRPV2 antibody at 4.51μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 86 kDa
      Observed band size: 86 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA897571LA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • IHC image of CSB-PA897571LA01HU diluted at 1:800 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品描述：

    The rabbit anti-human TRPV2 polyclonal antibody is an IgG antibody produced in rabbits that specifically recognizes and binds to the human and mouse TRPV2 protein. Its immunogen is the recombinant human TRPV2 protein (1-117aa). Protein G purification of this TRPV2 antibody brought it a purity of up to 95%. The specificity and reliability of this TRPV2 antibody have been verified in ELISA, WB, IHC, and IF applications.

    TRPV2 is primarily expressed in sensory neurons and regulates pain perception, body temperature, and cell survival. In particular, TRPV2 has been implicated in the regulation of cell proliferation, migration, and differentiation, as well as the modulation of synaptic plasticity in the nervous system. TRPV2 dysregulation is associated with various pathological conditions, including chronic pain, cancer, and neurodegenerative diseases.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRPV2 Polyclonal antibody
  • Uniprot No.：
    Q9Y5S1
  • 基因名：
  • 别名：
    TRPV2; VRL; Transient receptor potential cation channel subfamily V member 2; TrpV2; Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Transient receptor potential cation channel subfamily V member 2 protein (1-117AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRPV2 Antibody (CSB-PA897571LA01HU)，的标记方式是Non-conjugated。对于TRPV2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA897571LB01HU TRPV2 Antibody, HRP conjugated ELISA
    FITC CSB-PA897571LC01HU TRPV2 Antibody, FITC conjugated
    Biotin CSB-PA897571LD01HU TRPV2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.
  • 基因功能参考文献：
    1. TRPV2 mediates IL-8 secretion and calcium signaling in testicular peritubular cells. PMID: 30235802
    2. TRPV2 expression was inversely correlated with CRP and TpI and directly correlated with serum IGF-1. We assume that peripheral TRPV2 downregulation occurs concomitantly with the accumulation of TRPV2-white blood cells in the peri-infarct zone. TRPV2 may thus represent a novel target for treatment in the acute phase after MI. PMID: 29393104
    3. the expression of transient receptor potential vanilloid-1 (TRPV1), transient receptor potential vanilloid-2 (TRPV2) and transient receptor potential vanilloid-3 (TRPV3) channels in native human odontoblasts, was examined. PMID: 28905239
    4. High TRPV2 expression is associated with breast cancer. PMID: 26993604
    5. Binding of capsaicin to TRPV2_Quad antagonizes resiniferatoxin-induced activation likely through competition for the same binding sites. PMID: 27298359
    6. both TRPV2 and TRPV4 are involved in migration of human cardiac c-kit(+) progenitor cells. PMID: 26865051
    7. The results of the study show that polymorphism of TRPV2 influenced the susceptibility to FM. PMID: 27079220
    8. CGRP- and TRPV2-containing trigeminal neurons probably innervate the paranasal sinus mucosae, and project into spinal and principal trigeminal sensory nuclei. PMID: 27553072
    9. transient receptor potential vanilloid 2 is an intracellular Ca(2+)-permeable transient receptor potential vanilloid channel upregulated by nerve growth factor via the mitogen-activated protein kinase signaling pathway to augment neurite outgrowth. PMID: 26416880
    10. Using multiple sequence alignments as source for evolutionary, bioinformatics and statistical analysis, we have analyzed the evolutionary profiles for TRPV1, TRPV2, TRPV3 and TRPV4 PMID: 25333484
    11. There appears to be TRPV1- or TRPV2-IR sympathetic pathway in the human stellate ganglion and spinal cord. PMID: 25641129
    12. This study evaluated the role of Trpv2 in arthritis and the pharmacological effects of Trpv2 agonists. PMID: 25869297
    13. High expression of TRPV2 mRNA was closely associated with advanced pathological stage and worse survival of patients with esophageal squamous cell carcinoma. PMID: 24878697
    14. Aim of this review is to study the role of the TRPV2 channel, a member of the TRPV subfamily of TRP channels, in tumor progression. [review] PMID: 25001513
    15. TRPV1-, TRPV2-, P2X3-, and parvalbumin-immunoreactivity neurons in the human nodose ganglion innervate the pharynx and epiglottis through the pharyngeal branch and superior laryngeal nerve PMID: 24764033
    16. Data indicate that transient receptor potential vanilloid 2 (TRPV2) siRNA virtually abolished stretch-activated current. PMID: 25268680
    17. An upregulation in the expression of vanilloid transient potential channels 2 enhances hypotonicity-induced cytosolic Ca(2) rise in human induced pluripotent stem cell model of Hutchinson-Gillford Progeria. PMID: 24475260
    18. Sarcolemmal TRPV2 accumulation appears to have considerable pathological impact on Dilated cardiomyopathy (DCM) progression. PMID: 23786999
    19. The addition of TRPV2 inhibitor Tranilast in the incubation medium prevent the calcium influx triggered by lysoPC and reduced lysoPC-induced cytotoxicity,whereas TRPV4 inhibitor RN 1734 was without effect PMID: 23964684
    20. TRPV2 mediates adrenomedullin stimulation of prostate and urothelial cancer cell adhesion, migration and invasion. PMID: 23741410
    21. TRPV1 and TRPV2 are potential targets for potential therapeutic interventions in cardiovascular disease. PMID: 23453732
    22. Duchenne muscular dystrophy primary human myotubes exhibit abnormal elevation of TRPV2-dependant cation entry. PMID: 23426965
    23. TRPV2 plays a key role in mast-cell degranulation in response to mechanical, heat and red laser-light stimulation. PMID: 21574765
    24. The increased expression of TRPV2 gene in peripheral lymphocytes is closely correlated with childhood asthma in the north of China. PMID: 23294145
    25. TRPV2-coupled signaling as a key player in mediating the cellular actions of heat shock on DCs PMID: 23542034
    26. Cultivated HCjE cells and human conjunctiva express TRPV2, mRNA. PMID: 22327830
    27. Human corneal epithelial cells possess thermosensitive TRPV2 activity. PMID: 21506114
    28. A calmodulin binding site was located in the C-termini of TRPV2 (654-683) and TRPV5 (587-616). PMID: 20686800
    29. Decrease in membrane phosphatidylinositol 4,5-bisphosphate (PIP2) levels on channel activation underlies a major component of divalent calcium ion-dependent desensitization of TRPV2 and may play a similar role in other TRP channels. PMID: 20926660
    30. TRPV2 negatively controls glioma cell survival and proliferation, as well as resistance to Fas-induced apoptotic cell death in an ERK-dependent manner. PMID: 20093382
    31. Findings establish a role for TRPV2 in PCa progression to the aggressive castration-resistant stage, prompting evaluation of TRPV2 as a potential prognostic marker and therapeutic target in the setting of advanced PCa. PMID: 20103638
    32. TRPV2 plays a role in human hepatocarcinogenesis and might be a prognostic marker of patients with hepatocellular carcinoma (HCC). PMID: 20113837
    33. TRPV2 and PKA have roles as a signaling module for transduction of physical stimuli in mast cells PMID: 15249591
    34. It is concluded that PI3-kinase induces or modulates the activity of recombinant TRPV2 channels; in contrast to the previously proposed mechanism, activation of TRPV2 channels by PI3-kinase is not due to channel translocation to the plasma membrane. PMID: 16533525
    35. Both TRPV1 and TRPV2 are found in human peripheral blood lymphocytes. PMID: 16777226
    36. The TRPV2 ARD provides the first structural insight into a domain that coordinates nociceptive sensory transduction and is likely to be a prototype for other TRPV channel ARDs PMID: 16882997
    37. A progressive loss of s-TRPV2 accompanied by an increase of hTRPV2 expression was found in high-grade and -stage UC. PMID: 17977643
    38. Messenger RNA transcripts of TRPVs 1 through 4 are detected for the first time in human pulmonary artery smooth muscle cells. PMID: 18787888
    39. relative gene expression ofTRPV1-4 in leukocytes is: TRPV3 < TRPV4, TRPV1 and TRPV2; leukocytes in hyposensitive subjects showed up-regulation of TRPV1, which was almost doubly expressed PMID: 18983665
    40. The reduction of TRPV2 and TRPM8 immunoreactive nerve fibers in skin from individuals with Norrbottnian congenital insensitivity to pain further suggests that these ion channels are expressed primarily on nociceptive primary sensory neurons. PMID: 19482060
    41. TRPV1-immunoreactivity was significantly higher and TRPV2-immunoreactivity was significantly lower in peripheral blood mononuclear cells from end-stage kidney disease patients compared to controls. PMID: 19619644

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cytoplasm. Melanosome.
  • 蛋白家族：
    Transient receptor (TC 1.A.4) family, TrpV subfamily, TRPV2 sub-subfamily
  • 数据库链接：

    HGNC: 18082

    OMIM: 606676

    KEGG: hsa:51393

    STRING: 9606.ENSP00000342222

    UniGene: Hs.279746