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  4. TRPM7 Antibody

TRPM7 Antibody

  • 货号：
    CSB-PA690154
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA690154(TRPM7 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q96QT4
  • 基因名：
  • 别名：
    ALSPDC antibody; CHAK antibody; CHAK1 antibody; Channel kinase 1 antibody; Channel-kinase 1 antibody; Long transient receptor potential channel 7 antibody; LTrpC-7 antibody; LTrpC7 antibody; Transient receptor potential cation channel subfamily M member 7 antibody; TRP PLIK antibody; TRPM7 antibody; TRPM7_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human TRPM7
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1).
  • 基因功能参考文献：
    1. Data show that melastatin-related transient receptor potential member 7 (TRPM7)-K1648R mutant leads to disruption of protease or purinergic receptor-induced calcium release. PMID: 29500477
    2. Phosphorylation of S1565 within the exchange domain functions as a regulatory switch to control TRPM7 catalytic activity. PMID: 28220887
    3. These findings confirm that TRPM6 cannot be replaced by TRPM7, and that TRPM6/7 complexes and TRPM6/7-mediated Mg(2+) influx are indispensable in human epithelial colon cells. PMID: 29912157
    4. results identify SOX4 as a transcription factor that is uniquely sensitive to cellular tension and indicate that TRPM7 may contribute to breast cancer progression by tensional regulation of SOX4. PMID: 29684587
    5. Mg ions up-regulated the expression of Runx2 and alkaline phosphatase (ALP) through TRPM7/PI3K signalling pathway, which could significantly enhance the osteogenic activity of human osteoblasts. PMID: 28882757
    6. forms functional intracellular channels that mediate Zn2+ release from the lumen of a previously unrecognized population of vesicles during oxidative stress PMID: 28696294
    7. Malfunctions of TRPM7 are associated with anoxic neuronal death, cardiac fibrosis, tumor progression and macrothrombocytopenia. (Review) PMID: 28356194
    8. s observed that the expression of TRPM7 was significantly elevated in bladder cancer tissues compared with that noted in the adjacent non-tumor tissues. Furthermore, increased TRPM7 expression was significantly associated with recurrence, metastasis and prognosis. PMID: 28791418
    9. TRPM7 role in epithelial-mesenchymal transition, cell migration and invasion in prostate cancer cells PMID: 28573641
    10. our results in vitro and in vivo have revealed that the downregulation of TRPM7 could reduce the BCa cell proliferation, trigger cell cycle arrest and apoptosis. In conclusion, downregulated TRPM7 could reduce the activity of bladder cancer cells and induce cell apoptosis via ERK1/2 pathway. PMID: 27662662
    11. We have shown the contributions of TRPM7 in many physiological and pathophysiological processes, including hypoxia and ischaemia [review]. PMID: 27891609
    12. TRPM7 appears to play an important role in mechanosensing in mesenchymal stem cells. (Review) PMID: 27651019
    13. Our results show that the activating TRPM7 channel may prevent AD-related Abeta neuropathology via modulating Ca(2+)-regulated basal autophagy. PMID: 28870815
    14. The results suggest that TRPM7 is required for proliferation, migration and invasion of ovarian cancer cells through regulating multiple signaling transduction pathways and the formation of focal adhesions. PMID: 25450691
    15. The melastatin-like transient receptor potential cation channel, subfamily M, member 7 (TRPM7), which is responsible for Mg(2+) entry, was studies and [Mg(2+)]i measured in cells stably expressing wildtype CFTR, and two mutant proteins (DeltaF508-CFTR and G551D-CFTR). This study shows for the first time that [Mg(2+)]i is decreased in cells expressing DeltaF508-CFTR and G551D-CFTR mutated proteins. PMID: 26874684
    16. Variability of the TRPM7 current density in human cardiomyocytes is related to the clinical history, being higher in atrial fibrillation and in ischemic cardiomyopathy. PMID: 28129376
    17. our results show that TRPM7 is involved in PDAC cell invasion through regulation of Hsp90alpha/uPA/MMP-2 proteolytic axis, confirming that this channel could be a promising biomarker and possibly a target for PDAC metastasis therapy. PMID: 28284058
    18. Data show that activated TRPM7 activity contributes to the devastating migratory and invasive characteristics of glioblastoma (GBM) . PMID: 28061441
    19. Bradykinin promoted migration and invasion of hepatocellular carcinoma cells through TRPM7 and MMP2. PMID: 27693494
    20. chronic aldosterone treatment increases the plasma membrane expression of TRPM7, which is associated with an increase of TRPM7 current. This process occurs via an MR-dependent, genomic signaling cascade involving SGK1 and a functioning TRPM7 alpha-kinase domain. PMID: 27466368
    21. expression of TRPM7 has an impact on the prognosis of patients with esophageal squamous cell carcinoma PMID: 28314277
    22. TRPM7 is part of a large cytoskeletal complex that may affect the malignant potential of tumor cells by regulating actomyosin dynamics and cell-matrix interactions. PMID: 27402209
    23. TRPM7 and STAT3 activation might be critical for the growth of NPC cells. PMID: 26779625
    24. Data show that resistant cells express lower amounts of the transient receptor potential cation channel subfamily M TRPM6 and 7, both involved in magnesium transport. PMID: 26563869
    25. TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice. PMID: 27020697
    26. These results suggest that TRPM7 channel may play a critical role for zinc toxicity associated with stress. PMID: 26780729
    27. The Different Roles of The Channel-Kinases TRPM6 and TRPM7 PMID: 26179995
    28. TRPM7 inhibition by siRNA caused an increase in adhesion relative to control, but a decrease to 80% of calcium response relative to non-targeting siRNA which confirms the important role of TRPM7 in mechanotransduction despite the increase in adhesion. PMID: 25946314
    29. TRPM7 was involved in the regulation of hDPSC proliferation, migration and osteogenic differentiation and may play a role in the dental pulp repair process PMID: 24138320
    30. Overexpression of TRPM7 expression is significantly associated with poor prognosis in patients with ovarian cancer. PMID: 24935580
    31. TRPM7 expression closely associates with the migratory and metastatic properties of neuroblastoma cells in vitro and in vivo. TRPM7 controls a developmental transcriptional program involving the transcription factor SNAI2. PMID: 25797249
    32. Study demonstrates that human glioma cells express functional TRPM7 channel and that activation of this channel plays an important role in the proliferation, migration, and invasion of malignant glioma cells PMID: 25438992
    33. These results identified a central role of TRPM7 in MSC mechanical stimulation-induced osteogenesis PMID: 25263397
    34. When TRPM7 channel expression was induced from HEK293 cells in a nutrient-rich condition, LC3-II level increased indicating the increased level of basal autophagy. PMID: 25983327
    35. N-Myc can promote neuroblastoma cell proliferation through up-regulation of the channel kinases TRPM6 and TRPM7 PMID: 25277194
    36. Data show that lipopolysaccharide induced vascular endothelial cell migration is mediated by toll-like receptor TLR-4/NF-kappa B pathway and enzyme NAD(P)H oxidase in association with the transient receptor potential melastatin 7 (TRPM7) ion channel. PMID: 25130439
    37. The TRPM7 single-nucleotide polymorphisms (rs8042919 and rs7173321) are associated with breast cancer in Han Population of Northeast China. PMID: 24952306
    38. TRPM7 activates JAK2/STAT3 and/or Notch signaling pathways and leads to increased cell proliferation and migration. PMID: 25192910
    39. Data suggest that the TRPM7 channel negatively regulates the function of vascular endothelial cells. PMID: 25472964
    40. TRPM7 has been associated with cell proliferation, survival and development and thus correlated with growth and progression of several types of tumor cells PMID: 25069584
    41. High TRPM7 expression is associated with nasopharyngeal carcinoma. PMID: 25304381
    42. Data indicate heteromer formation between channel kinases TRPM6 and TRPM7 influences the biological activity of the ion channels. PMID: 24858416
    43. TRPM7 is a key protein involved in the mechanism underlying endotoxin-induced endothelial fibrosis PMID: 24710004
    44. Characterized the spatiotemporal evolution of intracellular calcium 'flickers', a signature of cell activation, in response to steady, pulsatile, and oscillatory shear stress, related to the opening of a stretch activated ion channel, TRPM7. PMID: 24445362
    45. TRPM7 could be essential for initiation and/or progression of prostate cancer. PMID: 24769209
    46. TRPM7 channels play an important role in hyperglycemia-induced injury of vascular endothelial cells PMID: 24223965
    47. Study shows that in normal tissues and cell lines, the kinase is proteolytically cleaved from the channel domain in a cell-type-specific manner. These TRPM7 cleaved kinase fragments (M7CKs) translocate to the nucleus and bind multiple components of chromatin-remodeling complexes, including Polycomb group proteins. PMID: 24855944
    48. Human lung fibroblasts express functional TRPM7 channels that may play a vital role in modulating cell proliferation and differentiation, probably involved in the PI3K/Akt pathway. PMID: 23934071
    49. TRPM6 modulates the functionality of TRPM7, and the TRPM6 kinase plays a critical role in tuning the phenotype of the TRPM7.M6 channel complex. PMID: 24385424
    50. TRPM7 alpha-kinase modulates inflammatory signaling by aldosterone in a TRPM7 channel/ Mg2+-independent manner. PMID: 23838006

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  • 相关疾病：
    Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (ALS-PDC1)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily; Transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM7 sub-subfamily
  • 数据库链接：

    HGNC: 17994

    OMIM: 105500

    KEGG: hsa:54822

    STRING: 9606.ENSP00000320239

    UniGene: Hs.512894