Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. TRO Antibody

TRO Antibody

  • 货号：
    CSB-PA025069LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA025069LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRO Polyclonal antibody
  • Uniprot No.：
    Q12816
  • 基因名：
    TRO
  • 别名：
    TRO antibody; KIAA1114 antibody; MAGED3 antibody; Trophinin antibody; MAGE-D3 antigen antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Trophinin protein (1-164AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRO Antibody (CSB-PA025069LA01HU)，的标记方式是Non-conjugated。对于TRO Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA025069LB01HU TRO Antibody, HRP conjugated ELISA
    FITC CSB-PA025069LC01HU TRO Antibody, FITC conjugated
    Biotin CSB-PA025069LD01HU TRO Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion.
  • 基因功能参考文献：
    1. Expression of trophinin and dipeptidyl peptidase IV in endometrial co-culture in the presence of an embryo: A comparative immunocytochemical study. PMID: 27035766
    2. report dual roles for trophinin in human cancers in terms of promoting malignancy in some tumor types and suppressing it in others PMID: 22201876
    3. Trophinin induced apoptosis in endometrial epithelial cells through protein kinase C-delta. PMID: 21191175
    4. infertile women with endometriosis or unexplained infertility had significantly weakened trophinin expression in the endometrium in the mid-luteal phase PMID: 12297480
    5. HCG from the human embryo induces trophinin expression by maternal cells. Unique role of hCG and trophinin in human embryo implantation, including the pathogenesis of ectopic pregnancy. PMID: 14633596
    6. Maged3 expression is restricted to the central nervous system where it was mostly detected in postmitotic neurons PMID: 15162511
    7. Fluorescence photobleaching of GFP-trophinin expressed in COS-1 cells showed the stable association of trophinin with the nuclear envelope. PMID: 16288751
    8. trophinin-mediated cell adhesion functions as a molecular switch for trophectoderm activation in human embryo implantation PMID: 17360433
    9. results suggest that trophinin promotes colorectal cancer invasion through a mechanism involving HMGB1/RAGE PMID: 17487845
    10. Trophinin functions as an adhesion molecule on the cell surface and as a molecular switch for trophoblast activation in the cytoplasm. PMID: 17495530
    11. Confocal microscopy analysis of ectopically expressed magphinins revealed that magphinin-alpha and -beta localize in the cytoplasm, whereas magphinin-gamma lacking the peptide encoded by exon-3 is nuclear. PMID: 17559068
    12. When magphinin-gamma was expressed in NIH3T3 cells, cells underwent G1 arrest. These results suggest that human magphinin-gamma inhibits cell cycle progression through nuclear activity. PMID: 17559068
    13. These findings underscore the importance of TRO in tumorigenesis, and suggest that TRO may be a useful biomarker for cisplatin sensitivity and invasive potential. PMID: 17597582
    14. results provide a mechanism for trophinin-mediated adhesion of human blastocyst to endometrium by a spatially and temporally restricted paracrine effect of hCG derived from the blastocyst PMID: 18078818
    15. Overexpression of trophinin leads to a more invasive phenotype and metastatic potential in human gallbladder cancer transfected into nude mice. PMID: 18846386
    16. TROPHONIN (TRO) is among the genes most downregulated by RAS. TRO expression is higher in cisplatin-sensitive cancer cell lines and positively correlates with prognoses in ovarian cancers. PMID: 17597582

    显示更多

    收起更多

  • 组织特异性：
    Strong expression at implantation sites. Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week
  • 数据库链接：

    HGNC: 12326

    OMIM: 300132

    KEGG: hsa:7216

    STRING: 9606.ENSP00000173898

    UniGene: Hs.633653