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TRIM41 Antibody

  • 货号：
    CSB-PA024479GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WV44
  • 基因名：
    TRIM41
  • 别名：
    E3 ubiquitin-protein ligase TRIM41 antibody; MGC1127 antibody; MGC31991 antibody; RINCK antibody; RING finger protein that interacts with C kinase antibody; RING finger-interacting protein with C kinase antibody; TRI41_HUMAN antibody; Trim41 antibody; Tripartite motif containing 41 antibody; Tripartite motif-containing protein 41 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRIM41
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Participates in innate antiviral response also by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response.
  • 基因功能参考文献：
    1. Taking these observations together, TRIM41 is a constitutively expressed intrinsic influenza A virus restriction factor that targets viral NP for ubiquitination and protein degradation. PMID: 29899090
    2. observed in the cytoplasm and the nucleus; nuclear transport is mediated by an N-terminal segment common to both alpha and beta isoforms, but independent of a classical nuclear localization signal sequence. PMID: 16022281
    3. RINCK is an E3 ligase that specifically recognizes the C1 domain of PKC isoforms PMID: 17893151
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Expressed in multiple tissues with the highest levels in heart and skeletal muscle.
  • 数据库链接：

    HGNC: 19013

    OMIM: 610530

    KEGG: hsa:90933

    STRING: 9606.ENSP00000320869

    UniGene: Hs.441488