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  4. TRIM31 Antibody

TRIM31 Antibody

  • 货号：
    CSB-PA290336
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA290336(TRIM31 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA290336(TRIM31 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human stomach cancer tissue, Primary antibody: CSB-PA290336(TRIM31 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他：

产品详情

  • Uniprot No.：
    Q9BZY9
  • 基因名：
    TRIM31
  • 别名：
    TRIM31 antibody; C6orf13 antibody; RNF antibody; E3 ubiquitin-protein ligase TRIM31 antibody; EC 2.3.2.27 antibody; RING-type E3 ubiquitin transferase TRIM31 antibody; Tripartite motif-containing protein 31 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human TRIM31
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:10-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of Src-induced anchorage independent cell growth. May have E3 ubiquitin-protein ligase activity.
  • 基因功能参考文献：
    1. knockdown of TRIM31 reduced the expression of MMP2, MMP9 and phospho-Akt. PMID: 29864908
    2. TRIM31 could promote hepatocellular carcinoma progression by targeting TSC1-TSC2 complex for degradation and further overactivating mTORC1 pathway. PMID: 28967907
    3. feedback suppressor of NLRP3 inflammasome activity PMID: 27929086
    4. Study reports that TRIM31 plays a critical role in the formation of autolysosomes in Atg5-/-or Atg7-/- cells, thus promoting elimination of invading bacteria through an Atg5- or Atg7-independent alternative pathway in the intestinal cells. PMID: 27216961
    5. TRIM31 gene expression is regulated by miR-551b in ovarian cancer. PMID: 27743201
    6. TRIM31 directly binds to NSE4, suggesting the existence of a TRIM31-MAGEA1-NSE4 complex reminiscent of the NSE1-NSE3-NSE4 trimer. PMID: 25590999
    7. TRIM31 might serve as a tumor suppressor in non-small cell lung cancer. PMID: 24566900
    8. The cellular level of TRIM31, an RBCC protein overexpressed in gastric cancer, is regulated by multiple mechanisms including the ubiquitin-proteasome system. PMID: 21231912
    9. The TRIm31 gene is related to intelligence in an ADHD background. PMID: 21302343

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  • 亚细胞定位：
    Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Up-regulated in gastric adenocarcinomas.
  • 数据库链接：

    HGNC: 16289

    OMIM: 609316

    KEGG: hsa:11074

    STRING: 9606.ENSP00000365924

    UniGene: Hs.493275