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TRIM23 Antibody

  • 货号：
    CSB-PA024459ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TRIM23 antibody at 2.67 μg/ml + Raw264.7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 65, 64, 62 kDa
      Observed band size: 65 kDa
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA024459ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRIM23 Polyclonal antibody
  • Uniprot No.：
    P36406
  • 基因名：
    TRIM23
  • 别名：
    ADP ribosylation factor domain protein 1 antibody; ADP-ribosylation factor domain-containing protein 1 antibody; ARF domain protein 1 antibody; ARFD1 antibody; E3 ubiquitin-protein ligase TRIM23 antibody; GTP binding protein ARD 1 antibody; GTP-binding protein ARD-1 antibody; N-acetyltransferase ARD1 human homolog of antibody; N-acetyltransferase homolog of S. cerevisiae ARD1 antibody; RING finger protein 46 antibody; TRI23_HUMAN antibody; TRIM23 antibody; Tripartite motif protein TRIM23 antibody; Tripartite motif-containing protein 23 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase TRIM23 protein (1-280AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes.; (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection.
  • 基因功能参考文献：
    1. TRIM23 may be associated with progression of gastric cancer PMID: 30477642
    2. work identifies the TRIM23-TBK1-p62 axis as a key component of selective autophagy and further reveals a role for K27-linked ubiquitination in GTPase-dependent TBK1 activation PMID: 28871090
    3. Our results indicate that TRIM23 enzymatic activity requires RING dimerization, consistent with the general model of TRIM activation PMID: 28681414
    4. TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2. PMID: 25905670
    5. conclude that TRIM23-mediated ubiquitin conjugation to NEMO is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses PMID: 20724660
    6. Data are consistent with a potential function for ADP-ribosylation factor domain protein 1 as an E3 ubiquitin ligase in cells. PMID: 15684077
    7. The s present a novel role for TRIM23 that is specific to UL144-mediated activation of NF-kappaB during the course of virus infection. PMID: 19176615

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  • 亚细胞定位：
    Cytoplasm. Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Note=Membrane-associated with the Golgi complex and lysosomal structures.
  • 蛋白家族：
    Small GTPase superfamily, Arf family
  • 数据库链接：

    HGNC: 660

    OMIM: 601747

    KEGG: hsa:373

    STRING: 9606.ENSP00000231524

    UniGene: Hs.792