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  4. TRIM2 Antibody

TRIM2 Antibody

  • 货号：
    CSB-PA024456GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9C040
  • 基因名：
    TRIM2
  • 别名：
    E3 ubiquitin protein ligase TRIM2 antibody; KIAA0517 antibody; RING finger protein 86 antibody; RNF86 antibody; Trim2 antibody; TRIM2_HUMAN antibody; Tripartite motif containing 2 antibody; Tripartite motif protein 2 antibody; Tripartite motif protein TRIM2 antibody; Tripartite motif-containing 2 antibody; Tripartite motif-containing protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TRIM2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
  • 基因功能参考文献：
    1. Study revealed that TRIM2 performs important functions in regulating the development and metastasis of osteosarcoma. PMID: 30066883
    2. TRIM2 is associated with clinical fibrotic phenotypes of eosinophilic esophagitis. PMID: 29628359
    3. We found that CREBRF and TRIM2 mRNA were significantly upregulated by rHDL, particularly in response to its phospholipid component 1-palmitoyl-2-linoleoyl-phosphatidylcholine, however, protein expression was not significantly altered. PMID: 29958463
    4. TRIM2 homozygous missense mutation (c.2000A>C; p.D667A) in a patient with peripheral neuropathy and bilateral vocal cord paralysis PMID: 25893792
    5. The functional role of the C-terminal NHL domain was characterized in TRIM2. PMID: 24817735
    6. TRIM2 is repressed by miR-9 and -181c, either alone or in combination. PMID: 21720722

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  • 相关疾病：
    Charcot-Marie-Tooth disease 2R (CMT2R)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    TRIM/RBCC family
  • 数据库链接：

    HGNC: 15974

    OMIM: 614141

    KEGG: hsa:23321

    STRING: 9606.ENSP00000339659

    UniGene: Hs.435711