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TRIM14 Antibody

  • 货号：
    CSB-PA577609
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA577609(TRIM14 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q14142
  • 基因名：
    TRIM14
  • 别名：
    5830400N10Rik antibody; KIAA0129 antibody; pub antibody; TRI14_HUMAN antibody; TRIM14 antibody; tripartite motif protein 14 antibody; tripartite motif protein TRIM14 antibody; tripartite motif-containing 14 antibody; Tripartite motif-containing protein 14 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human TRIM14
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.
  • 基因功能参考文献：
    1. Results showed that TRIM14 is increased in gastric cancer (GC) tissues and cell lines and associated with malignant features and unfavorable prognosis. Gain and lossoffunctional data confirmed that TRIM14 promotes migration, invasion and EMT progression by activating AKT signaling. TRIM14 was found to function as an oncogene in regulating EMT and metastasis of GC via AKT signaling, which was regulated by miR195. PMID: 30272351
    2. Our findings collectively suggest that TRIM14 functions as an oncogene by upregulating the AKT signaling pathway in osteosarcoma cells, supporting its potential utility as a therapeutic target for this disease. PMID: 28205534
    3. Study shows that tripartite Motif 14 (TRIM14) is a putative tumor suppressor and regulator of innate immune response in non-small cell lung cancer. The functional data establishes a novel tumor suppressive role for TRIM14 in non-small cell lung cancer progression. PMID: 28059079
    4. we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p. Therefore, we reason that the tumor suppressor role of miR-195-5p in oral squamous cell carcinoma is dependent on the interaction with TRIM14. PMID: 29204446
    5. In searching for mechanisms how TRIM14 exerts its antiviral function we found that TRIM14 interacted with HCV encoded non-structural protein NS5A and could strongly induce its degradation dependent on the NS5A1 subdomain. Interestingly extensive domain mapping analyses revealed that NS5A degradation was mediated by the highly conserved SPRY domain of TRIM14, which might involve the K48 ubiquitination pathway PMID: 27578425
    6. findings define the WHIP-TRIM14-PPP6C mitochondrial signalosome required for RIG-I-mediated innate antiviral immunity. PMID: 29053956
    7. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response PMID: 28476934
    8. survival of xenograft mice was prolonged by BsAbBmi/TRIM treatment compared to either AbBmi-1 or AbTRIM-14 treatment. In conclusion, these results provided new evidence that BsAbBmi/TRIM inhibited the progression of osteosarcoma, which suggest that BsAbBmi/TRIM may be a novel anti-cancer agent for osteosarcoma therapy PMID: 28631557
    9. MiR-15b degrades TRIM14 in oral tongue squamous cell cancer.TRIM14 role in oral tongue squamous cell cancer resistance to cisplatin. PMID: 28350138
    10. Data suggest that tripartite motif containing 14 protein (TRIM14) might play an important role in the malignant progression of tongue squamous cells carcinoma (TSCC) and in regulation of the NF_Kappa B (NF-kappaB) signaling pathway. PMID: 26799420
    11. stable enhanced expression of trim14 gene in cells activates the transcription of many immunity genes and suppresses Sindbis virus reproduction, but Sindbis virus infection of HEK-trim14 cells promotes inhibition of some genes involved in innate immunity. PMID: 25948474
    12. Upon virus infection, TRIM14 recruits NF-kappaB essential modulator (NEMO) to the MAVS complex via ubiquitin chains. PMID: 24379373

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  • 亚细胞定位：
    Mitochondrion outer membrane. Cytoplasmic vesicle, phagosome.
  • 蛋白家族：
    TRIM/RBCC family
  • 组织特异性：
    Highest expression in liver; undetectable in skeletal muscle.
  • 数据库链接：

    HGNC: 16283

    OMIM: 606556

    KEGG: hsa:9830

    STRING: 9606.ENSP00000343990

    UniGene: Hs.575631