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TREH Antibody

  • 货号：
    CSB-PA024402LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA024402LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TREH Polyclonal antibody
  • Uniprot No.：
    O43280
  • 基因名：
    TREH
  • 别名：
    Alpha alpha trehalase antibody; Alpha alpha trehalose glucohydrolase antibody; Alpha antibody; alpha-trehalase antibody; alpha-trehalose glucohydrolase antibody; Brush border membrane glycoprotein antibody; MGC129621 antibody; TRE antibody; TREA antibody; TREA_HUMAN antibody; TREH antibody; Trehalase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Trehalase protein (373-507AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TREH Antibody (CSB-PA024402LA01HU)，的标记方式是Non-conjugated。对于TREH Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA024402LB01HU TREH Antibody, HRP conjugated ELISA
    FITC CSB-PA024402LC01HU TREH Antibody, FITC conjugated
    Biotin CSB-PA024402LD01HU TREH Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose.
  • 基因功能参考文献：
    1. these results indicate that trehalose has anti-apoptotic effects through the suppression of oxidative stress-induced mitochondrial injury and ER stress which is dependent on the promotion of autophagic flux and the induction of selective autophagy PMID: 28981117
    2. In conclusion, we identified four novel loci (TGFA, PIK3R1, FGFR3 and TREH) and confirmed two loci known to be associated with cartilage thickness.The identified associations were not caused by rare exonic variants. This is the first report linking TGFA to human Osteoarthritis, which may serve as a new target for future therapies. PMID: 27701424
    3. results suggest a significant association between the RETL1, TREH, and PHLDB1 genes and GBM development in the Han Chinese population PMID: 26156397
    4. variants in TREH control trehalase activity, and although one of these variants is also reproducibly associated with T2D, it is likely that the effect of the SNP on risk of T2D occurs by a mechanism different than affecting trehalase activity. PMID: 23468175
    5. we found three protective alleles for glioma patients, including the allele ''T'' of rs17748 in the TREH gene by recessive model (OR, 0.48; 95% CI, 0.23-1.01; P = 0.05) analysis PMID: 22369735
    6. These results suggest that TREH acts as a stress-response protein in the kidney rather than involved in utilization of exogenous trehalose. PMID: 19126402

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  • 相关疾病：
    Deficiency of TREH results in isolated trehalose intolerance that causes gastrointestinal symptoms after ingestion of edible mushrooms.
  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Glycosyl hydrolase 37 family
  • 组织特异性：
    Expressed in kidney, liver and small intestine. Also more weakly expressed in pancreas.
  • 数据库链接：

    HGNC: 12266

    OMIM: 275360

    KEGG: hsa:11181

    STRING: 9606.ENSP00000264029

    UniGene: Hs.129712