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TRDMT1 Antibody

  • 货号：
    CSB-PA675694LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat heart tissue
      All lanes: TRDMT1 antibody at 4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 45, 42, 40, 7, 8, 13 kDa
      Observed band size: 45 kDa
    • IHC image of CSB-PA675694LA01HU diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRDMT1 Polyclonal antibody
  • Uniprot No.：
    O14717
  • 基因名：
    TRDMT1
  • 别名：
    dDNMT antibody; DmMT 2 antibody; DmMT2 antibody; DNA (cytosine 5 ) methyltransferase 2 antibody; DNA (cytosine 5) methyltransferase like protein 2 antibody; DNA (cytosine-5)-methyltransferase-like protein 2 antibody; DNA 5 cytosine methyltransferase antibody; DNA methyltransferase 2 antibody; DNA methyltransferase homolog HsaIIP antibody; DNA MTase homolog HsaIIP antibody; Dnmt 2 antibody; Dnmt2 antibody; M.HsaIIP antibody; MHsaIIP antibody; nmt 2 antibody; nmt2 antibody; OTTHUMP00000045198 antibody; PuMet antibody; RNMT 1 antibody; RNMT1 antibody; TRDMT 1 antibody; TRDMT_HUMAN antibody; TRDMT1 antibody; tRNA (cytosine 5 ) methyltransferase antibody; tRNA (cytosine(38)-C(5))-methyltransferase antibody; tRNA aspartic acid methyltransferase 1 antibody; tRNA aspartic acid methyltransferase 1 variant 1 antibody; tRNA aspartic acid methyltransferase 1 variant 2 antibody; tRNA aspartic acid methyltransferase 1 variant 3 antibody; tRNA aspartic acid methyltransferase 1 variant 4 antibody; tRNA aspartic acid methyltransferase 1 variant 5 antibody; tRNA aspartic acid methyltransferase 1 variant 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human tRNA (cytosine(38)-C(5))-methyltransferase protein (170-269AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRDMT1 Antibody (CSB-PA675694LA01HU)，的标记方式是Non-conjugated。对于TRDMT1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA675694LB01HU TRDMT1 Antibody, HRP conjugated ELISA
    FITC CSB-PA675694LC01HU TRDMT1 Antibody, FITC conjugated
    Biotin CSB-PA675694LD01HU TRDMT1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
  • 基因功能参考文献：
    1. Data suggest that, upon HIV-1 infection, DNMT2 is re-localized from the nucleus to cytoplasmic stress granules where DNMT2 methylates HIV-1 messenger RNA; this methylation increases the stability of the HIV-1 RNA genome and up-regulates virus replication; thus, DNMT2 appears to facilitate HIV-1 infection. PMID: 28476776
    2. The strong effect of some of the somatic cancer mutations on DNMT2 activity suggests that these mutations have a functional role in tumorigenesis. PMID: 25747896
    3. Mapped is the tRNA binding site of DNMT2 by systematically mutating surface-exposed lysine and arginine residues to alanine and studying the tRNA methylation activity and binding of the corresponding variants. PMID: 22591353
    4. the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection. PMID: 20864816
    5. identification of residual DNA-(cytosine-C5) methyltransferase activity PMID: 12794065
    6. cDNA microarray analysis identified several genes involved in DNA methylation, such as DNMT2 and DNMT3a that were more highly expressed in LNCaP-r (an androgen sensitive prostate cancer cell line). PMID: 16173030
    7. genetic and biochemical approach revealed that DNMT2 did not methylate DNA but instead methylated aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop PMID: 16424344
    8. An association study of 45 folate-related genes in spina bifida: Involvement of tRNA aspartic acid methyltransferase 1 (TRDMT1) PMID: 19161160

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
  • 组织特异性：
    Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 2977

    OMIM: 602478

    KEGG: hsa:1787

    STRING: 9606.ENSP00000367030

    UniGene: Hs.351665