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TRAPPC9 Antibody

  • 货号：
    CSB-PA842741LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA842741LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA842741LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TRAPPC9 Polyclonal antibody
  • Uniprot No.：
    Q96Q05
  • 基因名：
    TRAPPC9
  • 别名：
    TRAPPC9 antibody; KIAA1882 antibody; NIBP antibody; T1 antibody; Trafficking protein particle complex subunit 9 antibody; NIK- and IKBKB-binding protein antibody; Tularik gene 1 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Trafficking protein particle complex subunit 9 protein (780-1030AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TRAPPC9 Antibody (CSB-PA842741LA01HU)，的标记方式是Non-conjugated。对于TRAPPC9 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA842741LB01HU TRAPPC9 Antibody, HRP conjugated ELISA
    FITC CSB-PA842741LC01HU TRAPPC9 Antibody, FITC conjugated
    Biotin CSB-PA842741LD01HU TRAPPC9 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi.
  • 基因功能参考文献：
    1. CNVs significantly contribute to the mutational spectrum of TRAPPC9 gene associated with syndromic intellectual disability. PMID: 29187737
    2. Data show that NIBP expression level is high in gastric cancer (GC) patients and indicate that the NIBPregulated NFkappaB signaling pathway plays a pivotal role in the chemoresistance of GC cells by promoting EMT. PMID: 29620292
    3. Homozygous TRAPPC9 gene nonsense mutation in OXTR gene is associated with intellectual disability, speech disorder, and secondary microcephaly. PMID: 29031008
    4. In this study, we report that WES analysis allowed identification of the causal molecular lesion in both patients. In the first family of Egyptian origin, a homozygous nonsense mutation (c.1423C>T; p.Arg377*) in TRAPPC9 was identified PMID: 27108886
    5. In conclusion, we demonstrated that NIBP knockdown reduces colorectal cancer metastasis through down-regulation of canonical NF-kappaBeta signaling and suppression of ERK and JNK signaling. PMID: 28125661
    6. NIBP impacts on the expression levels of Ecadherin, CD44 and vimentin via the NFkappaB classical and alternative pathways. PMID: 27109343
    7. NIBP reflects a higher metastatic potential of CRC tumors, and its mechanism of action may be through regulation of the classical NF-kappaB pathway and increased MMP-2 and MMP-9 expression PMID: 26596835
    8. Data identified important roles of NIBP in promoting tumorigenesis via NFkappaBeta signaling. PMID: 25704885
    9. Identification and construction of a 3D protein model of trafficking protein particle complex 9 (TRAPPC9), a potetnially interesting molecular target for the development of drug therapy against non syndromic mental retardation PMID: 24040793
    10. By detailed phenotypic analysis of our patients, and by critical literature review, we found that homozygous TRAPPC9 loss-of-function mutations cause a distinctive phenotype, characterized by peculiar facial appearance, obesity, hypotonia PMID: 22549410
    11. A homozygous splice site mutation in TRAPPC9 causes intellectual disability and microcephaly. PMID: 22989526
    12. Data suggest that TRAPPC9 serves to uncouple p150(Glued) from the COPII coat, and to relay the vesicle-dynactin interaction at the target membrane. PMID: 22279557
    13. Data show that a disease-causing mutation of TRAPPC2, D47Y, failed to interact with either TRAPPC9 or TRAPPC8, suggesting that aspartate 47 in TRAPPC2 is at or near the site of interaction with TRAPPC9 or TRAPPC8. PMID: 21858081
    14. Studies indicate that a truncation of TRAPPC9 leads to mental retardation. PMID: 20966969
    15. TRAPPC9 has a role in brain development, possibly through its effect on NF-kappaB activation and protein trafficking in the postmitotic neurons of the cerebral cortex PMID: 20004763
    16. TRAPPC9, encodes the NIK- and IKK-beta-binding protein, has a role in nonsyndromic autosomal-recessive mental retardation PMID: 20004765
    17. NIBP is a NIK and IKK(beta)-binding protein that enhances NF-(kappa)B activation PMID: 15951441

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  • 相关疾病：
    Mental retardation, autosomal recessive 13 (MRT13)
  • 亚细胞定位：
    Golgi apparatus, cis-Golgi network. Endoplasmic reticulum. Cytoplasm.
  • 蛋白家族：
    NIBP family
  • 组织特异性：
    Expressed at high levels in muscle and kidney and to a lower extent in brain, heart and placenta.
  • 数据库链接：

    HGNC: 30832

    OMIM: 611966

    KEGG: hsa:83696

    STRING: 9606.ENSP00000373979

    UniGene: Hs.654911