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TRAF3IP1 Antibody

  • 货号：
    CSB-PA008682
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8TDR0
  • 基因名：
    TRAF3IP1
  • 别名：
    Interleukin 13 receptor alpha 1 binding protein 1 antibody; Interleukin-13 receptor alpha 1-binding protein 1 antibody; Microtubule interacting protein that associates with TRAF3 antibody; Microtubule-interacting protein associated with TRAF3 antibody; MIP T3 antibody; MIP-T3 antibody; MIPT3 antibody; MIPT3_HUMAN antibody; TNF receptor associated factor 3 interacting protein 1 antibody; TRAF3-interacting protein 1 antibody; Traf3ip1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human MIP-T3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis.
  • 基因功能参考文献：
    1. Mutations in TRAF3IP1 are identified in patients with nephronophthisis and retinal degeneration. The identified mutations result in mild ciliary defects in patients and reveal a role of IFT54 as a negative regulator of microtubule stability via MAP4. PMID: 26487268
    2. MIP-T3 functions as a negative regulator of the innate type I interferon response by preventing TRAF3 from forming protein complexes with critical downstream transducers and effectors of antiviral response. PMID: 22079989
    3. Data show that MIP-T3 protein level is highly regulated; mainly mediated by the ubiquitin-proteasome system. PMID: 21510943
    4. The interaction of MIP-T3 with both actin filaments and microtubule suggested that MIP-T3 may play an important role in regulation of cytoskeleton dynamics in cells. PMID: 20391533
    5. These results suggest that MIP-T3 is a novel inhibitor of IL-13 signaling and may be a useful molecule in ameliorating various conditions in which IL-13 plays a central role. PMID: 12935900

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  • 相关疾病：
    Senior-Loken syndrome 9 (SLSN9)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    TRAF3IP1 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 17861

    OMIM: 607380

    KEGG: hsa:26146

    STRING: 9606.ENSP00000362424

    UniGene: Hs.631898