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TPTE2 Antibody

  • 货号：
    CSB-PA757850LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA757850LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TPTE2 Polyclonal antibody
  • Uniprot No.：
    Q6XPS3
  • 基因名：
    TPTE2
  • 别名：
    TPTE2; TPIP; Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Lipid phosphatase TPIP; TPTE and PTEN homologous inositol lipid phosphatase
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 protein (167-411AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TPTE2 Antibody (CSB-PA757850LA01HU)，的标记方式是Non-conjugated。对于TPTE2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA757850LB01HU TPTE2 Antibody, HRP conjugated ELISA
    FITC CSB-PA757850LC01HU TPTE2 Antibody, FITC conjugated
    Biotin CSB-PA757850LD01HU TPTE2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate.; Shows no phosphoinositide phosphatase activity.
  • 基因功能参考文献：
    1. The role of TPTE2 in gallbladder cancer cells PMID: 25676706
    2. TPTE2 was originally reported to be a phosphoinositide 3'-phosphatase, like the tumor suppressor PTEN. Later on, other homologous phosphatases, such as Ci-VSP and Dr-VSP, have been described. These proteins are 5'-phosphatases. More recently, using a chimeric construct, we have shown that the catalytic domain of TPTE2 behaves as a 5'-phosphatase as well. PMID: 22896666
    3. findings suggest that C2-domain of TPIP-C2 may act as a dominant negative effector, which may bind to and arrest the cell proliferation signalling complex PMID: 22311048
    4. the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells PMID: 22164291
  • 亚细胞定位：
    [Isoform 3]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.; [Isoform 4]: Cytoplasm.
  • 组织特异性：
    Isoform 3 is expressed in testis, brain and stomach while isoform 4 seems to be testis-specific.
  • 数据库链接：

    HGNC: 17299

    OMIM: 606791

    KEGG: hsa:93492

    STRING: 9606.ENSP00000372437

    UniGene: Hs.377488