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TPST1 Antibody

  • 货号：
    CSB-PA024132LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Rat liver tissue, Mouse liver tissue, Mouse kidney tissue
      All lanes: TPST1 antibody at 2.4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 43 kDa
      Observed band size: 50 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA024132LA01HU at dilution of 1:100
    • Western Blot
      Positive WB detected in: HepG2 whole cell lysate, Hela whole cell lysate, SH-SY5Y whole cell lysate, U251 whole cell lysate, PC-3 whole cell lysate, 293 whole cell lysate, A549 whole cell lysate
      All lanes: TPST1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 43 kDa
      Observed band size: 43 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TPST1 Polyclonal antibody
  • Uniprot No.：
    O60507
  • 基因名：
    TPST1
  • 别名：
    TPST1; Protein-tyrosine sulfotransferase 1; Tyrosylprotein sulfotransferase 1; TPST-1
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human Protein-tyrosine sulfotransferase 1 protein (283-370AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TPST1 Antibody (CSB-PA024132LA01HU)，的标记方式是Non-conjugated。对于TPST1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA024132LB01HU TPST1 Antibody, HRP conjugated ELISA
    FITC CSB-PA024132LC01HU TPST1 Antibody, FITC conjugated
    Biotin CSB-PA024132LD01HU TPST1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
  • 基因功能参考文献：
    1. TPST1 was significantly negatively correlated with the expression of cMet in lung cancer and may be a negative prognostic biomarker of lung cancer. PMID: 26238632
    2. TPST1 rs3757417T>G polymorphisms are associated with colorectal cancer. PMID: 25079514
    3. Affinity purified salivary TPST showed a single band of 50-54 kDa and is the first report characterizing a tyrosylprotein sulfotransferase in secretory fluid from the parotid gland PMID: 16244708
    4. results exclude TPST1 as the causative gene for Shwachman-Diamond syndrome PMID: 12032733
    5. Shear stress-dependent downregulation of TPST1 in human endothelium involves protein kinase C PMID: 12056800
    6. Human tyrosylprotein sulfotransferase may be functional as homodimer/oligomer in the trans-Golgi compartment. PMID: 16859706

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Protein sulfotransferase family
  • 组织特异性：
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 数据库链接：

    HGNC: 12020

    OMIM: 603125

    KEGG: hsa:8460

    STRING: 9606.ENSP00000302413

    UniGene: Hs.421194