TPM4 Antibody
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货号:CSB-PA024108GA01HU
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规格:¥3,900
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其他:
产品详情
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Uniprot No.:P67936
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基因名:
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别名:epididymis secretory protein Li 108 antibody; HEL-S-108 antibody; TM30p1 antibody; TMP 4 antibody; TPM4 antibody; TPM4_HUMAN antibody; Tropomyosin 4 antibody; Tropomyosin alpha 4 chain antibody; Tropomyosin alpha-4 chain antibody; Tropomyosin-4 antibody; wu:fb06e07 antibody; zgc:103436 antibody; zgc:63909 antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Human TPM4
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免疫原种属:Homo sapiens (Human)
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抗体亚型:IgG
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纯化方式:Antigen Affinity purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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产品提供形式:Liquid
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应用范围:ELISA,WB,IHC
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Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.
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基因功能参考文献:
- TPM4 is associated with clinical progression in colon cancer patients and acts as a tumor suppressor in colon cancer cells. PMID: 29455030
- Tpm4.1 is essential to maintain cell-cell adhesions and to inhibit abnormal increases in cell migration and invasion, which are important to prevent invasion and metastasis of breast cancer cells. PMID: 28431393
- findings demonstrate a nonredundant role for TPM4 in platelet biogenesis in humans and mice and reveal that truncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder. PMID: 28134622
- Results show that Tpm4.2 facilitates the transition of NM-2A to the strongly actin-binding myosin-ADP state. PMID: 26847712
- Data indicate the upregulation of tropomyosin-4 in infiltrating ductal breast carcinomas (IDCAs) tissues, which may suggest its involvement in breast cancer development. PMID: 23812729
- TPM4, PDIA and SRC8 were also localized to the trophoblast cells, further highlighting the importance of these cytoskeletal remodelling proteins in early pregnancy PMID: 21373848
- Low TPM4 expression in the cytoplasm is associated with uterine cervix carcinogenesis. PMID: 21119665
- Tm4-defined cytoskeleton is a marker of growth and repair/regeneration in response to injury, disease state and stress in skeletal muscle. PMID: 17968984
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亚细胞定位:Cytoplasm, cytoskeleton.
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蛋白家族:Tropomyosin family
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组织特异性:Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets o
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数据库链接:
HGNC: 12013
OMIM: 600317
KEGG: hsa:7171
UniGene: Hs.631618
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