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TP53INP2 Antibody

  • 货号：
    CSB-PA040129
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8IXH6
  • 基因名：
  • 别名：
    C20orf110 antibody; Diabetes and obesity regulated, p53 inducible protein U antibody; DOR antibody; p53-inducible protein U antibody; PIG-U antibody; PINH antibody; T53I2_HUMAN antibody; Tp53inp2 antibody; Tumor protein p53-inducible nuclear protein 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human TP53INP2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
  • 基因功能参考文献：
    1. TP53INP2 promotes ribosome biogenesis through facilitating rRNA synthesis at the nucleolus PMID: 27172002
    2. We conducted a replication study using a dataset outside of the Challenge, and found the association between TP53INP2 and ER-negative breast cancer was significant (p = 5.07x10-3). Expression of HP (16q22.2) showed a suggestive association with ER-negative breast cancer in the discovery phase (Z = 4.30, p = 1.70x10-5) although the association was not significant after Bonferroni adjustment. PMID: 28957356
    3. The results reveal the association of TP53INP2-related basal autophagy with cell growth and malignant progression of human liposarcoma. PMID: 28131096
    4. nucleolus integrity is not essential for both DOR nucleo-cytoplasmic shuttling and DOR function on basal autophagy PMID: 22750142
    5. Mutation of conserved hydrophobic residues in region 1 of TP53inp2 reduces transcriptional activity, and blocks nuclear exit and autophagic activity under autophagy-activated conditions. PMID: 22470510
    6. DOR plays an important role in thyroid hormone-mediated osteoblast differentiation, and a DOR SNP associates with plasma osteocalcin in men. PMID: 21467300
    7. TP53INP2 is a novel gene involved in the autophagy of mammalian cells. PMID: 19056683
    8. Alternative splicing of an exon in the 5' untranslated region of a gene termed TP53INP2 is a key event downstream of hnRNP A2 that is necessary for cells to invade the extracellular matrix. PMID: 19934309

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  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
  • 数据库链接：

    HGNC: 16104

    OMIM: 617549

    KEGG: hsa:58476

    STRING: 9606.ENSP00000363942

    UniGene: Hs.516994