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TP53I3 Antibody

  • 货号：
    CSB-PA003784
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using PIG3 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q53FA7
  • 基因名：
  • 别名：
    p53 induced gene 3 protein antibody; p53-induced gene 3 protein antibody; Putative quinone oxidoreductase antibody; QORX_HUMAN antibody; quinone oxidoreductase homolog antibody; Quinone oxidoreductase PIG3 antibody; TP53I3 antibody; Tumor protein p53 inducible protein 3 antibody; Tumor protein p53-inducible protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human PIG3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro).
  • 基因功能参考文献：
    1. Results revealed that PIG3 expression levels positively correlated with poor prognosis of non-small cell lung cancer (NSCLC) patients and indicate that PIG3 promotes NSCLC progression. PMID: 28259183
    2. Data suggest that PIG3 was involved in HIF-1alpha regulation, and indicate a signaling pathway of PIG3/HIF-1alpha in the regulation of cell migration in renal cell carcinoma. PMID: 27029070
    3. our data suggest that high expression of p53-inducible gene 3 is significant for glioblastoma inhibition and p53-inducible gene 3 independently indicates good prognosis in patients, which might be a novel prognostic biomarker or potential therapeutic target in glioblastoma. PMID: 28351326
    4. Data indicate that knockdown of p53-induced gene 3 (PIG-3) expression by small interfering RNA (siRNA) treatment can inhibit the generation of reactive oxygen species (ROS). PMID: 26472723
    5. The results suggested that PIG3 plays an oncogenic role in PTC via the regulation of the PI3K/AKT/PTEN pathway and support the exploration of PIG3 as a novel biomarker for patients with papillary thyroid carcinoma PMID: 26133772
    6. PIG3, which functions in DNA damage repair, uses an unexpected catalytic mechanism to suppress Rho-ROCK activity and impair tumor invasion in vivo. This regulation was suppressed by antioxidants. PMID: 26464464
    7. prohibitin and prohibiton (PHB2) contribute to PIG3-mediated apoptosis by binding to the PIG3 promoter (TGYCC)15 motif PMID: 24388982
    8. study provides evidence that the variant genotypes of (TGYCC)n repeats in the PIG3 promoter are functional and associated with risk of squamous cell carcinoma of the head and neck in a non-Hispanic white population PMID: 23241165
    9. a novel signaling pathway of GPx3-PIG3 in the regulation of cell death in prostate cancer. PMID: 22461624
    10. certain p53 mutatants activate PIG3, whereas the result of our study show increased full-length transcript expression in tumor counterparts PMID: 20603616
    11. Results suggest that PIG3 is a critical component of the DNA damage response pathway and has a direct role in the transmission of the DNA damage signal from damaged DNA to the intra-S and G2/M checkpoint machinery. PMID: 20023697
    12. p53 activity and PIG3 gene function are uncoupled by UV-dependent alternative splicing through rapid proteolytic degradation PMID: 15067011
    13. suppression of p53-C277Y by RNAi reduced pig3 promoter activity, RNA, and protein expression PMID: 15192123
    14. numerous factors contribute to the normal alternative splicing of PIG3 exon 4 and UV-inducible increases in this process require that the splicing of this exon be maintained in a sufficiently weakened state under normal conditi PMID: 18801469
    15. PIG3 action is through oxidative stress produced by its enzymatic activity and provides essential knowledge for eventual control of apoptosis. PMID: 19349281

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  • 蛋白家族：
    Zinc-containing alcohol dehydrogenase family, Quinone oxidoreductase subfamily
  • 数据库链接：

    HGNC: 19373

    OMIM: 605171

    KEGG: hsa:9540

    STRING: 9606.ENSP00000238721

    UniGene: Hs.50649