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TOM1L1 Antibody

  • 货号：
    CSB-PA024044LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA024044LA01HU diluted at 1:240 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA024044LA01HU at 1:105, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TOM1L1 Polyclonal antibody
  • Uniprot No.：
    O75674
  • 基因名：
    TOM1L1
  • 别名：
    2310045L10Rik antibody; C80573 antibody; OK/KNS CL.3 antibody; Src activating and signaling molecule antibody; Src activating and signaling molecule protein antibody; Src-activating and signaling molecule protein antibody; SRCASM antibody; Target of Myb like protein 1 antibody; Target of Myb-like protein 1 antibody; Target of myb1 (chicken) homolog like 1 antibody; Target of myb1 (chicken) like 1 antibody; Target of myb1 like 1 antibody; TM1L1_HUMAN antibody; TOM1 L1 antibody; TOM1 like protein 1 antibody; TOM1-like protein 1 antibody; TOM1L1 antibody; TOM1L1 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human TOM1-like protein 1 protein (296-476AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TOM1L1 Antibody (CSB-PA024044LA01HU)，的标记方式是Non-conjugated。对于TOM1L1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA024044LB01HU TOM1L1 Antibody, HRP conjugated ELISA
    FITC CSB-PA024044LC01HU TOM1L1 Antibody, FITC conjugated
    Biotin CSB-PA024044LD01HU TOM1L1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions.
  • 基因功能参考文献：
    1. TOM1L1 enhances ERBB2-induced cell invasiveness by promoting invadopodia formation and MT1-MMP trafficking to the plasma membrane. PMID: 26899482
    2. whereas TOM1L1 depletion only slightly affected SRC-induced proliferation of colorectal cancer cells in vitro, it drastically decreased tumor growth in xenografted nude mice. PMID: 23023324
    3. This pattern of Srcasm expression suggests that it may act as a negative regulator in esophageal squamous cell carcinoma cell signaling PMID: 20944134
    4. results imply that TOM1L has a mitogenic effect in Jurkat T-cells and is involved in a novel cell signaling pathway that is crucial for the IL-2 production and STAT3 expression PMID: 20182632
    5. Srcasm plays a role in linking EGF receptor- and SFK-dependent signaling to differentiation in keratinocytes PMID: 15579470
    6. Tom1L1 could act as an intermediary between signaling and degradative pathways. PMID: 15611048
    7. study found that not only the PTAP sequence in the GAT domain but also the PSAP sequence in the C-terminal region of Tom1L1 is responsible for its interaction with the UEV domain of Tsg101 and competes with the HIV-1 Gag protein for the Tsg101 interaction PMID: 18367816
    8. All multicentric and nodular basal cell carcinomas displayed a prominent loss of Srcasm staining in association with a marked increase in Ki-67 staining. PMID: 19220627
    9. Participation of Tom1L1 in EGF-stimulated endocytosis of EGF receptor. PMID: 19798056

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  • 亚细胞定位：
    Golgi apparatus, Golgi stack. Endosome membrane. Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    TOM1 family
  • 数据库链接：

    HGNC: 11983

    OMIM: 604701

    KEGG: hsa:10040

    STRING: 9606.ENSP00000460823

    UniGene: Hs.153504