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TOB2 Antibody

  • 货号：
    CSB-PA617901ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA617901ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA617901ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TOB2 Polyclonal antibody
  • Uniprot No.：
    Q14106
  • 基因名：
    TOB2
  • 别名：
    KIAA1663 antibody; Protein Tob2 antibody; Protein Tob4 antibody; Tob2 antibody; TOB2_HUMAN antibody; TOB4 antibody; Transducer of erbB 2 2 antibody; Transducer of erbB-2 2 antibody; Transducer of ERBB2, 2 antibody; TROB2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein Tob2 protein (1-70AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
  • 基因功能参考文献：
    1. Results show reduced Tob2 expression in primary hepatocellular Carcinoma cells (HCC) and that dysregulation of miR-362 and Tob2 may contribute to HCC malignancy. PMID: 25649327
    2. study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation PMID: 21242960
    3. TNFalpha is able to transactivate ErbB-2 and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals. PMID: 19760502
    4. Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy. PMID: 19940862
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    BTG family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 11980

    OMIM: 607396

    KEGG: hsa:10766

    STRING: 9606.ENSP00000331305

    UniGene: Hs.474978