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TNR Antibody

  • 货号：
    CSB-PA340307LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA340307LA01HU diluted at 1:500 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNR Polyclonal antibody
  • Uniprot No.：
    Q92752
  • 基因名：
  • 别名：
    Janusin antibody; MGC149328 antibody; Restrictin antibody; Tenascin R (restrictin, janusin) antibody; Tenascin-R antibody; TENR_HUMAN antibody; TN-R antibody; Tnr antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tenascin-R protein (1231-1319AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNR Antibody (CSB-PA340307LA01HU)，的标记方式是Non-conjugated。对于TNR Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA340307LB01HU TNR Antibody, HRP conjugated ELISA
    FITC CSB-PA340307LC01HU TNR Antibody, FITC conjugated
    Biotin CSB-PA340307LD01HU TNR Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.
  • 基因功能参考文献：
    1. Two genes, TNR (and TNK2), were found to have genetic variations linked to familial Parkinson's Disease. PMID: 26595808
    2. TnC and TnR play important roles in nervous and immune systems. [Review] PMID: 23269478
    3. citation presents comparison with human gene. PMID: 12927810
    4. results show that tenascin-R expression is tightly regulated in a spatiotemporal manner during brain development, especially cortical plate formation; its pattern of expression suggests a role for tenascin-R in corticogenesis PMID: 21456020
    5. KIAA0510, the 3'-untranslated region of the tenascin-R gene, and tenascin-R are overexpressed in pilocytic astrocytomas PMID: 20202125
    6. The researchers found evidence that the tenascin R gene is a potential susceptiblity or marker gene for IgA nephropathy. PMID: 19890582
    7. Tenascin R is expressed and glycosylated in neurons PMID: 14681222
    8. An extracellular matrix molecule TNR and its associated carbohydrate human natural killer cell glycan (HNK-1) provide conditions beneficial for induction of long-term potentiation in the hippocampus. PMID: 17537973
    9. Clinical trial of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19573479

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Tenascin family
  • 组织特异性：
    Brain specific.
  • 数据库链接：

    HGNC: 11953

    OMIM: 601995

    KEGG: hsa:7143

    STRING: 9606.ENSP00000263525

    UniGene: Hs.659864