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TNNT1 Antibody

  • 货号：
    CSB-PA024015GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    P13805
  • 基因名：
    TNNT1
  • 别名：
    ANM antibody; MGC104241 antibody; NEM5 antibody; Skeletal antibody; Slow antibody; slow skeletal muscle antibody; Slow skeletal muscle troponin T antibody; sTnT antibody; Tnnt1 antibody; TNNT1_HUMAN antibody; TNT antibody; TnTs antibody; Troponin T antibody; Troponin T slow skeletal muscle antibody; Troponin T type 1 (skeletal slow) antibody; troponin T1 skeletal slow antibody; Troponin T1, slow skeletal type antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TNNT1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能参考文献：
    1. High TNNT1 expression is associated with breast cancer. PMID: 30031058
    2. This study describes the first TNNT1 mutation that transmits in an autosomal dominant fashion to cause nemaline myopathy. PMID: 29178646
    3. investigated the effects of one of these mutations, K247R of TnT, on the picosecond dynamics of the Tn core domain (Tn-CD), consisting of TnC, TnI and TnT2 (183-288 residues of TnT), by carrying out the quasielastic neutron scattering measurements on the reconstituted Tn-CD containing either the wild-type TnT2 (wtTn-CD) or the mutant TnT2 (K247R-Tn-CD) in the absence and presence of Ca(2+) PMID: 28923663
    4. Data suggest that mutations in troponin C (TnC, A8V) and troponin T (TnT, delta14-TnT) found in patients with hypertrophic cardiomyopathy together fully stabilize the active M state of regulated actin (the actin-tropomyosin-troponin complex). PMID: 28530094
    5. pathogenesis of TNNT1 myopathies PMID: 27429059
    6. Copeptin and troponin T measurement could potentially improve the prehospital diagnostic and prognostic classification of patients with a suspected AMI. PMID: 27903076
    7. TNNT1 genetic and epigenetic variations are associated with HDL-C levels and coronary artery disease. PMID: 26950807
    8. Three homologous genes have evolved in vertebrates to encode three muscle type-specific TnT isoforms: TNNT1 for slow skeletal muscle TnT, TNNT2 for cardiac muscle TnT, and TNNT3 for fast skeletal muscle TnT. PMID: 26774798
    9. Nemaline body myopathy Palestinian patients were found to have a novel mutation in troponin T1. PMID: 26296490
    10. troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants PMID: 24625749
    11. Biopsy-proven acute and viral myocarditis is associated with elevated concentrations of hs-TnT. PMID: 24781421
    12. Troponin T1 blood levels had a positive association with increased risk for hypertrophic cardiomyopathy. PMID: 24020864
    13. TNNT1 DNA methylation levels were positively correlated with mean HDL particle size, HDL-phospholipid, HDL-apolipoprotein AI, HDL-C and TNNT1 expression levels. PMID: 23244308
    14. Human slow skeletal troponin T (HSSTnT) isoforms, despite being homologues of cardiac TnT may display distinct functional properties in muscle regulation. PMID: 22977240
    15. analysis of parameters of oxygen-dependent metabolism of neutrophils by NBT test and levels of vWF antigen in the serum can be used for predicting the risk of unfavorable outcome in patients with ACS and normal troponin T PMID: 22448368
    16. In heart failure patients with normal ejection fraction, highly sensitive troponin T and heart fatty acid binding protein are elevated independent of coronary artery disease. PMID: 21729325
    17. baseline cTnT levels are higher in patients with MPI evidence of reversible myocardial ischaemia than those without reversible ischaemia PMID: 22239123
    18. carotid-femoral pulse wave and office pulse pressure are associated with minimally elevated hsTnT levels in the elderly PMID: 21784424
    19. the hypertrophic phenotype associated with the TnT mutations can be characterized by a significant increase in disorder of rigor cross-bridges. PMID: 21683708
    20. Elevated serum troponin T levels are associated with different conditions related to the severity of hypertrophic cardiomyopathy. PMID: 21111984
    21. Cardiac troponin T and creatine kinase have roles in infarct size and left ventricular function after acute myocardial infarction PMID: 21448949
    22. The occurrence of myocardial infarction is associated with elevated troponin T levels. PMID: 19916752
    23. Among athletees, faster runners demonstrate significantly stronger cardoac TnT releases and inflammation signs. PMID: 20380359
    24. troponin-T mutations were responsible for 3% of the hypertrophic cardiomyopathy cases in our study population PMID: 20038417
    25. Troponin T may have a role in pulmonary embolism progeresion to death PMID: 19541721
    26. TNT is a biochemical marker of susceptibility to hypoxia in infants of type 1 diabetic mothers. PMID: 19690080
    27. Data suggest that inefficient incorporation into myofilament is responsible for the instability of mutant slow troponin T in Amish nemaline myopathy. PMID: 15665378
    28. Report adaptation by alternative RNA splicing of slow troponin T isoforms in type 1 but not type 2 Charcot-Marie-Tooth disease. PMID: 18579801
    29. slow TnT was encoded by two different transcripts in significantly different ratios in myotonic dystrophy type 1 and myotonic dystrophy type 2 muscles. PMID: 19326042

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  • 相关疾病：
    Nemaline myopathy 5 (NEM5)
  • 蛋白家族：
    Troponin T family
  • 数据库链接：

    HGNC: 11948

    OMIM: 191041

    KEGG: hsa:7138

    STRING: 9606.ENSP00000467176

    UniGene: Hs.631558