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TNNI2 Antibody

  • 货号：
    CSB-PA024012ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TNNI2 antibody at 3.83μg/ml + Mouse skeletal muscle tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 21 kDa
      Observed band size: 21 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA024012ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA024012ESR2HU at dilution of 1:100
    • Immunoprecipitating TNNI2 in Mouse skeletal muscle tissue
      Lane 1: Rabbit control IgG instead of CSB-PA024012ESR2HU in Mouse skeletal muscle tissue. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA024012ESR2HU (8μg) + Mouse skeletal muscle tissue (500μg)
      Lane 3: Mouse skeletal muscle tissue (10μg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNNI2 Polyclonal antibody
  • Uniprot No.：
    P48788
  • 基因名：
    TNNI2
  • 别名：
    AMCD 2B antibody; AMCD2B antibody; DA 2B antibody; DA2B antibody; fast skeletal muscle antibody; Fast twitch skeletal muscle troponin I antibody; fast-twitch isoform antibody; FSSV antibody; fsTnI antibody; TNNI 2 antibody; Tnni2 antibody; TNNI2_HUMAN antibody; tro antibody; Troponin I antibody; Troponin I fast skeletal muscle antibody; Troponin I fast twitch 2 antibody; Troponin I fast twitch isoform antibody; Troponin I fast twitch skeletal muscle isoform antibody; Troponin I skeletal fast antibody; Troponin I type 2 (skeletal fast) antibody; Troponin I type 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Troponin I, fast skeletal muscle protein (1-100AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
  • 基因功能参考文献：
    1. Mutations in genes encoding cardiac troponin I (TNNI3) and cardiac troponin T (TNNT2) caused altered troponin protein stoichiometry in patients with dilated cardiomyopathy. TNNI3p.98trunc resulted in haploinsufficiency, increased Ca(2+) -sensitivity and reduced length-dependent activation. TNNT2p.K217del caused increased passive tension. PMID: 28436080
    2. TNNI2 gene missense mutation is associated with distal arthrogryposis type 1. PMID: 26374086
    3. report the first TNNI2 mutation in classical FSS and describe an atypical adult FSS case with only facial contractures resulting from somatic mosaicism PMID: 23850728
    4. Molecular genetic investigations revealed pathogenic mutations in MYH3, TPM2, and TNNI2 in one sporadic and 19 familial cases of distal arthrogryposis. PMID: 22519952
    5. Atrial re-expression of ssTnI during paroxysmal atrial fibrillation in patients does not seem to be part of the process of AF-associated cardiomyocyte dedifferentiation but seems to result from transient cardiomyocyte stress at the onset of AF. PMID: 15289369
    6. study found a novel TNNI2 mutation in a Chinese family with distal arthrogryposis type 2B PMID: 16802141
    7. Implantation of stable human clone expressing fast-twitch skeletal muscle troponin I in female BALB/c nude mice inhibits primary tumor growth and suggests that grafts are self-inhibitory by halting angiogenesis. PMID: 17393089
    8. These findings reveal a new function for TNNI2 as a co-activator of ERRalpha. PMID: 18331830
    9. Data found that fTnI normally associated with fast twitch skeletal muscle were present at significant levels in the thoracic aorta, and that fTnI transcripts were expressed in the smooth muscle layer of mouse blood vessels of all sizes. PMID: 18548613
    10. Gene expression revealed up-regulation of pro-angiogenic (PGF), anti-apoptotics (BAG-1, BCL-2), heart development (TNNT2, TNNC1) and extracellular matrix remodelling (MMP-2, MMP-7) genes in SM. PMID: 18805052

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  • 相关疾病：
    Arthrogryposis, distal, 2B (DA2B)
  • 蛋白家族：
    Troponin I family
  • 数据库链接：

    HGNC: 11946

    OMIM: 191043

    KEGG: hsa:7136

    STRING: 9606.ENSP00000252898

    UniGene: Hs.523403