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TNIK Antibody

  • 货号：
    CSB-PA023998LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA023998LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023998LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA023998LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNIK Polyclonal antibody
  • Uniprot No.：
    Q9UKE5
  • 基因名：
  • 别名：
    EC 2.7.11.1 antibody; KIAA0551 antibody; Tnik antibody; TNIK_HUMAN antibody; Traf2 and NCK interacting kinase antibody; Traf2 and NCK-interacting protein kinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human TRAF2 and NCK-interacting protein kinase protein (523-714AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNIK Antibody (CSB-PA023998LA01HU)，的标记方式是Non-conjugated。对于TNIK Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023998LB01HU TNIK Antibody, HRP conjugated ELISA
    FITC CSB-PA023998LC01HU TNIK Antibody, FITC conjugated
    Biotin CSB-PA023998LD01HU TNIK Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
  • 基因功能参考文献：
    1. TNIK is required for the tumour-initiating function of colorectal cancer stem cells. Its inhibition is a promising therapeutic approach. PMID: 27562646
    2. Results indicate that Traf2- and Nck-interacting kinase (TNIK) is involved in the interleukin-6-dependent proliferation of multiple myeloma cells. PMID: 28467797
    3. results provide new evidence that TNIK may be involved in the proliferation of multiple myeloma IM-9 cells and in the anti-cancer activity of dovitinib via inhibition of the endogenous Wnt signaling pathway. PMID: 26995282
    4. Exome sequencing of the index in each family revealed the same homozygous truncating mutation in TNIK that results in complete loss of the protein. TNIK is a kinase with a well-established role in dendrite development and synaptic transmission. The phenotype we observe in human patients who lack TNIK is consistent with the previously published Tnik (-/-) phenotype in the murine model PMID: 27106596
    5. Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK PMID: 28334814
    6. Our results demonstrated that TNIK might play a crucial role in pancreatic carcinogenesis and serve as a novel therapeutic target of pancreatic cancer. PMID: 26269113
    7. High expression of TNIK in colorectal cancer was associated with recurrence in stage II and III colorectal cancer patients. PMID: 26499327
    8. Endogenous substrates of TNIK were identified in neurons, along with consensus sequences for TNIK. PMID: 26645429
    9. nuclear p-TNIK expression was studied in hepatocellular carcinoma, and p-TNIK nuclear expression was associated with poor prognosis and is a candidate prognostic marker for hepatocellular carcinoma PMID: 25160513
    10. Dynamic change of TNIK offers a way to protect cells from outside stimulus. PMID: 23355318
    11. TNIK mediates proliferation and survival of EBV-transformed B-cells. PMID: 22904686
    12. TNIK is essential for the activation of both the canonical Wnt pathway and the JNK pathway, and serves as a pro-survival factor. PMID: 21710359
    13. TNIK is a specific effector of Rap2 to regulate actin cytoskeleton PMID: 15342639

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  • 相关疾病：
    Mental retardation, autosomal recessive 54 (MRT54)
  • 亚细胞定位：
    Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 组织特异性：
    Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
  • 数据库链接：

    HGNC: 30765

    OMIM: 610005

    KEGG: hsa:23043

    STRING: 9606.ENSP00000399511

    UniGene: Hs.34024