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TNFRSF19 Antibody

  • 货号：
    CSB-PA878878LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate
      All lanes: TNFRSF19 antibody at 2.36μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47, 46, 31 kDa
      Observed band size: 47 kDa
    • Immunofluorescence staining of HepG2 cells with CSB-PA878878LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TNFRSF19 Polyclonal antibody
  • Uniprot No.：
    Q9NS68
  • 基因名：
    TNFRSF19
  • 别名：
    AL023044 antibody; AW123854 antibody; TAJ alpha antibody; TAJ antibody; TAJ-alpha antibody; TNFRSF19 antibody; TNFRSF19 tumor necrosis factor receptor superfamily, member 19 antibody; TNR19_HUMAN antibody; Toxicity and JNK inducer antibody; TRADE antibody; TROY antibody; Tumor necrosis factor receptor superfamily member 19 antibody; UNQ1888/PRO4333 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Tumor necrosis factor receptor superfamily member 19 protein (276-415AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TNFRSF19 Antibody (CSB-PA878878LA01HU)，的标记方式是Non-conjugated。对于TNFRSF19 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA878878LB01HU TNFRSF19 Antibody, HRP conjugated ELISA
    FITC CSB-PA878878LC01HU TNFRSF19 Antibody, FITC conjugated
    Biotin CSB-PA878878LD01HU TNFRSF19 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death.
  • 基因功能参考文献：
    1. TNFRSF19 may contribute to the development of colorectal tumors with deregulated beta-catenin activity. PMID: 24623448
    2. Results show aberrant expression and/or signaling by TROY as a contributor to the dispersion of glioblastoma cells and therapeutic resistance. PMID: 23699535
    3. the association of RhoGDIalpha with TROY contributed to TROY-dependent RhoA activation and neurite outgrowth inhibition after Nogo-66 stimulation. PMID: 24129566
    4. TROY is up-regulated in human colorectal cancer cell lines and in intestinal tumors in mice. It functions as a negative modulator of the Wnt pathway in LGR5-positive stem cells. PMID: 23142137
    5. study demonstrated that TNFR2 and TROY mRNA levels are enhanced in cutaneous squamous cell carcinoma cells compared to healthy ones in a Tunisian population PMID: 22057614
    6. TNFRSF19 overexpression in glioma cells activates Rac1 signaling in a Pyk2-dependent manner to drive glioma cell invasion and migration PMID: 20881009
    7. Findings provide new insights into the pathogenesis of NPC by highlighting the involvement of pathways related to TNFRSF19 and MDS1-EVI1 in addition to HLA molecules. PMID: 20512145
    8. TROY regulates melanoma growth. PMID: 17187358
    9. the ternary complex of NgR/TROY/LINGO-1 expressed on astrocytes, macrophages/microglia and neurones, by interacting with Nogo-A on oligodendrocytes, might modulate glial-neuronal interactions in demyelinating lesions of multiple sclerosis PMID: 17239012

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.
  • 数据库链接：

    HGNC: 11915

    OMIM: 606122

    KEGG: hsa:55504

    STRING: 9606.ENSP00000371693

    UniGene: Hs.149168