TNFAIP1 Antibody
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货号:CSB-PA934815
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规格:¥1100
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图片:
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA934815(TNFAIP1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA934815(TNFAIP1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
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其他:
产品详情
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Uniprot No.:Q13829
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基因名:TNFAIP1
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别名:TNFAIP1 antibody; BACURD2 antibody; EDP1BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 antibody; hBACURD2 antibody; BTB/POZ domain-containing protein TNFAIP1 antibody; Protein B12 antibody; Tumor necrosis factor antibody; alpha-induced protein 1 antibody; endothelial antibody
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宿主:Rabbit
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反应种属:Human,Mouse,Rat
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免疫原:Fusion protein of Human TNFAIP1
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
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抗体亚型:IgG
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纯化方式:Antigen affinity purification
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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产品提供形式:Liquid
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应用范围:ELISA,IHC
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推荐稀释比:
Application Recommended Dilution ELISA 1:2000-1:10000 IHC 1:50-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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靶点详情
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功能:Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
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基因功能参考文献:
- TNFAIP1 silence significantly increased the migrated and invaded cells compared to that in control, while these increases were abolished by miR-424 suppression. PMID: 28535539
- CREB is a negative regulator of the TNFAIP1 gene. PMID: 26398148
- TNFAIP1 plays an important role in mediating miR-15a dependent biological functions in osteosarcoma. PMID: 26261520
- MiR-181a played a critical role in regulating pancreatic cancer growth and migration, likely interacting with TNFAIP1. PMID: 26152285
- Results showed that the expression of TNFAIP1 protein was significantly increased in osteosarcoma tissues and associated with distant metastasis. PMID: 24969828
- Expression of TNFAIP1 is regulated by the transcriptional factor Sp1. PMID: 23912453
- TNFAIP1 inhibited the transcriptional activities of nuclear factor kappa B (NF-kappaB) and activating protein-1 reporters PMID: 22810651
- CK2 could phosphorylate TNFAIP1 in vitro and in vivo, which facilitated the distribution of TNFAIP1 in nucleus and enhanced its interaction with PCNA. PMID: 19851886
- The promoter region of human TNFAIP1 gene was functionally characterized. PMID: 19593659
- suggest that the TNFAIP1/POLDIP2 complex sense-antisense architecture represents a clinically significant transcriptional structural-functional gene module associated with amplification of the genomic region on 17q11.2 in breast cancer. PMID: 20158880
- TNFAIP1 shows increased transcript levels in Alzheimer's disease brains PMID: 12600716
- Expression levels of TNFAIP1 are high in COS7 and NIH3T3 cell lines but low in the cancer cell lines. PMID: 16870576
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亚细胞定位:Cytoplasm. Nucleus. Endosome. Note=Colocalizes with RHOB in endosomes.
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蛋白家族:BACURD family
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数据库链接:
HGNC: 11894
OMIM: 191161
KEGG: hsa:7126
STRING: 9606.ENSP00000226225
UniGene: Hs.76090
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