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TMOD1 Antibody

  • 货号：
    CSB-PA023909ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TMOD1 antibody at 1.85μg/ml
      Lane 1: Mouse brain tissue
      Lane 2: Mouse lung tissue
      Lane 3: Hela whole cell lysate
      Lane 4: K562 whole cell lysate
      Lane 5: A549 whole cell lysate
      Lane 6: MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 41, 27 kDa
      Observed band size: 41 kDa
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA023909ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA023909ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品描述：

    The immunization of rabbits with the recombinant human TMOD1 protein (1-359AA) and final purification from rabbit antiserum by antigen affinity purification causes the creation of the anti-TMOD1 antibody. This TMOD1 antibody is a polyclonal antibody and occurs as an unconjugated IgG. It is reactive with human and mouse TMOD1 protein, a tropomyosin (TM)-binding protein that exerts an important role in controlling the organization of actin filaments. And this anti-TMOD1 antibody has been validated for use in ELISA, WB, and IHC applications.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TMOD1 Polyclonal antibody
  • Uniprot No.：
    P28289
  • 基因名：
    TMOD1
  • 别名：
    D9S57E antibody; E Tmod antibody; E tropomodulin antibody; E-Tmod antibody; Erythrocyte tropomodulin antibody; ETMOD antibody; MGC124125 antibody; MGC124126 antibody; OTTHUMP00000021743 antibody; TMOD antibody; Tmod1 antibody; TMOD1 protein antibody; TMOD1_HUMAN antibody; Tropomodulin 1 antibody; Tropomodulin-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Tropomodulin-1 protein (1-359AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus.
  • 基因功能参考文献：
    1. Tmod1 function in mouse and human erythroblasts, was investigated. PMID: 28729432
    2. The mutation reduced binding affinity for both Lmod2 and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies . PMID: 26873245
    3. Study highlighted a novel TMOD1-mediated link between NF-kappaB activation and MMP13 induction, which accounts in part for the NF-kappaB-dependent malignant phenotype of TNBC. PMID: 25398440
    4. Tmod1 and Tmod3 showed somewhat different tropomyosin-binding site utilization. PMID: 24922351
    5. The structures and biochemical analysis of structure-inspired mutants showed that one Tmod molecule interacts with three actin subunits at the pointed end, while also contacting two tropomyosin molecules on each side of the filament. PMID: 25061212
    6. Tropomyosin requires an intact N-terminal coiled coil to interact with this protein PMID: 11964245
    7. levels of TM1, TM2 and TM3 are reduced in human transitional cell carcinoma cells, but significantly upregulated by inhibition of the mitogen-activated protein kinase-signaling pathway PMID: 15095301
    8. The N-terminal "KRK ring" may participate in balancing electrostatic force with hydrophobic interaction in dimerization of TM and its binding to E-Tmod. PMID: 16297372
    9. study identifies several amino acid residues on Tmod-1 that are important for its interaction with TM5 (a nonmuscle TM isoform) PMID: 16434395

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    Tropomodulin family
  • 组织特异性：
    Highly expressed in the erythrocyte, heart and skeletal muscle.
  • 数据库链接：

    HGNC: 11871

    OMIM: 190930

    KEGG: hsa:7111

    STRING: 9606.ENSP00000259365

    UniGene: Hs.404289