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TMEM65 Antibody

  • 货号：
    CSB-PA023869LA01HU
  • 规格：
    ￥3900
  • 图片：
    • Western Blot
      Positive WB detected in: PC-3 whole cell lysate, Hela whole cell lysate, MCF-7 whole cell lysate, 293 whole cell lysate, SH-SY5Y whole cell lysate, Mouse brain tissue
      All lanes: TMEM65 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 26 KDa
      Observed band size: 20-25 KDa
      Exposure time：5min
  • 其他：

产品详情

  • 产品描述：

    The use of recombinant human Transmembrane protein 65 protein to immunize the rabbit, subsequent collection of the rabbit serum, and the final isolation and purification of the antibody using antigen affinity method were used to produce the TMEM65 polyclonal antibody.

    The TMEM65 polyclonal antibody shows reactivity with TMEM65 protein from human and mouse samples. It has been validated to recognize TMEM65 protein in the ELISA and WB applications, suggesting the usefulness of this TMEM65 polyclonal antibody in various experimental settings.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TMEM65 Polyclonal antibody
  • Uniprot No.：
    Q6PI78
  • 基因名：
    TMEM65
  • 别名：
    TMEM65; Transmembrane protein 65
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Transmembrane protein 65 protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TMEM65 Antibody (CSB-PA023869LA01HU)，的标记方式是Non-conjugated。对于TMEM65 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023869LB01HU TMEM65 Antibody, HRP conjugated ELISA
    FITC CSB-PA023869LC01HU TMEM65 Antibody, FITC conjugated
    Biotin CSB-PA023869LD01HU TMEM65 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication. May also play a role in the regulation of mitochondrial respiration and mitochondrial DNA copy number maintenance.
  • 基因功能参考文献：
    1. A novel homozygous splice variant (c.472+1G>A) in the TMEM65 gene identified in a patient with mitochondrial encephalomyopathy. TMEM65 mutation severely affected mitochondrial content and respiration rate in dermal fibroblasts. PMID: 28295037
  • 相关疾病：
    Defects in TMEM65 may cause a mitochondrial disorder characterized by a complex encephalomyopathic phenotype. Clinical features includ microcephaly, dysmorphic features, psychomotor regression, hypotonia, growth retardation, lactic acidosis, intractable seizures, dyskenetics movements, without cardiomyopathy (PubMed:28295037).
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein.
  • 组织特异性：
    Predominantly expressed the ventricular tissue (at protein level).
  • 数据库链接：

    HGNC: 25203

    OMIM: 616609

    KEGG: hsa:157378

    STRING: 9606.ENSP00000297632

    UniGene: Hs.100691