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  4. TMEM175 Antibody

TMEM175 Antibody

  • 货号：
    CSB-PA023756GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BSA9
  • 基因名：
    TMEM175
  • 别名：
    TMEM175 antibody; Endosomal/lysosomal potassium channel TMEM175 antibody; Transmembrane protein 175 antibody; hTMEM175 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TMEM175
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Constitutes the pore-forming subunit of the lysoK(GF) complex, a complex activated by extracellular growth factors. The lysoK(GF) complex is composed of TMEM175 and AKT (AKT1, AKT2 or AKT3), a major target of growth factor receptors: in the complex, TMEM175 channel is opened by conformational changes by AKT, leading to its activation. The lysoK(GF) complex is required to protect neurons against stress-induced damage.
  • 基因功能参考文献：
    1. TMEM175 deficiency impairs lysosomal and mitochondrial function and increases alpha-synuclein aggregation. PMID: 28193887
    2. structure of TMEM175 represents a novel architecture of a tetrameric cation channel whose ion selectivity mechanism appears to be distinct from that of the classical K(+) channel family PMID: 28723891
    3. Data indicated that GBA and TMEM175/GAK significantly alter age at onset in PD. PMID: 25914293
  • 相关疾病：
    Parkinson disease (PARK)
  • 亚细胞定位：
    Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
  • 蛋白家族：
    TMEM175 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 28709

    OMIM: 168600

    KEGG: hsa:84286

    UniGene: Hs.478936