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TMEM165 Antibody

  • 货号：
    CSB-PA023739LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TMEM165 antibody at 8µg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 35, 29 kDa
      Observed band size: 35 kDa
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA023739LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA023739LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA023739LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TMEM165 Polyclonal antibody
  • Uniprot No.：
    Q9HC07
  • 基因名：
    TMEM165
  • 别名：
    TMEM165; TPARL; Transmembrane protein 165; Transmembrane protein PT27; Transmembrane protein TPARL
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transmembrane protein 165 protein (173-228AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TMEM165 Antibody (CSB-PA023739LA01HU)，的标记方式是Non-conjugated。对于TMEM165 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023739LB01HU TMEM165 Antibody, HRP conjugated ELISA
    FITC CSB-PA023739LC01HU TMEM165 Antibody, FITC conjugated
    Biotin CSB-PA023739LD01HU TMEM165 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation.
  • 基因功能参考文献：
    1. High TMEM165 expression is associated with hepatocellular carcinoma. PMID: 30015898
    2. The finding of numerous splice variants could lead to a family of TMEM165 isoforms. PMID: 28088503
    3. Data indicate the Golgi protein transmembrane protein 165 (TMEM165) as a manganese-sensitive protein in mammalian cells. PMID: 28270545
    4. This manuscript is a review of the current state of knowledge on TMEM165 deficiencies in Congenital Disorders of Glycosylation as well as new data on function of TMEM165 and some speculative models on TMEM165/Golgi functions are discussed. PMID: 27401145
    5. Study not only provides novel insights into the molecular causes of glycosylation defects observed in TMEM165-deficient cells but also suggests that TMEM165 is a key determinant for the regulation of Golgi Mn(2+) homeostasis. PMID: 27008884
    6. Antisense oligonucleotide-mediated pseudoexon skipping used in a Golgi-resident protein, a promising treatment option for a specific TMEM165-congenital disorders of glycosylation. PMID: 24720419
    7. Congenital Disorders of Glycosylation disease-causing mutations of TMEM165 changes subcellular localization of the protein. PMID: 23575229
    8. Defects in TMEM165 affect both Ca2+ and pH homeostasis. PMID: 23569283
    9. we identified TMEM165 (also named TPARL) as a gene involved in congenital disorders of glycosylation (CDG). PMID: 22683087

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  • 相关疾病：
    Congenital disorder of glycosylation 2K (CDG2K)
  • 亚细胞定位：
    Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane. Lysosome membrane. Early endosome membrane. Late endosome membrane.
  • 蛋白家族：
    GDT1 family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 30760

    OMIM: 614726

    KEGG: hsa:55858

    STRING: 9606.ENSP00000370736

    UniGene: Hs.479766