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TM4SF20 Antibody

  • 货号：
    CSB-PA709608LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA709608LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA709608LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TM4SF20 Polyclonal antibody
  • Uniprot No.：
    Q53R12
  • 基因名：
    TM4SF20
  • 别名：
    TM4SF20; UNQ518/PRO994; Transmembrane 4 L6 family member 20
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transmembrane 4 L6 family member 20 protein (114-184AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TM4SF20 Antibody (CSB-PA709608LA01HU)，的标记方式是Non-conjugated。对于TM4SF20 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA709608LB01HU TM4SF20 Antibody, HRP conjugated ELISA
    FITC CSB-PA709608LC01HU TM4SF20 Antibody, FITC conjugated
    Biotin CSB-PA709608LD01HU TM4SF20 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
  • 基因功能参考文献：
    1. Ceramide inverts the membrane orientation of TMS4SF20, creating a form of TM4SF20 that stimulates the cleavage of CREB3L1. PMID: 27499293
    2. TM4SF20 is the first protein shown to undergo Regulated Alternative Translocation in response to ceramide. In the absence of ceramide, the N terminus of the first transmembrane helix of TM4SF20 is inserted into the ER lumen. This form blocks activation of CREB3L1, a membrane-bound transcription factor. In the presence of ceramide, the membrane topology of TM4SF20 is inverted. The inverted form stimulates CREB3L1 cleavage. PMID: 27499293
    3. TM4SF20 ancestral deletion predisposes carriers to a pediatric disorder of early language delay and cerebral white matter hyperintensities. PMID: 23810381
  • 相关疾病：
    Specific language impairment 5 (SLI5)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    L6 tetraspanin family
  • 组织特异性：
    Expressed in the brain, with high levels in the parietal lobe, hippocampus, pons, white matter and cerebellum.
  • 数据库链接：

    HGNC: 26230

    OMIM: 615404

    KEGG: hsa:79853

    UniGene: Hs.156652