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TLE3 Antibody

  • 货号：
    CSB-PA023587GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q04726
  • 基因名：
    TLE3
  • 别名：
    E(sp1) homolog Drosophila antibody; Enhancer of split groucho 3 antibody; Enhancer of split groucho-like protein 3 antibody; ESG 3 antibody; ESG antibody; ESG3 antibody; FLJ39460 antibody; GRG 3 antibody; GRG3 antibody; HsT18976 antibody; KIAA1547 antibody; TLE 3 antibody; Tle3 antibody; TLE3_HUMAN antibody; Transducin like enhancer of split 3 antibody; Transducin like enhancer of split 3 homolog of Drosophila E(sp1) antibody; Transducin like enhancer protein 3 antibody; transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) antibody; Transducin-like enhancer protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TLE3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES.
  • 基因功能参考文献：
    1. Patients with TLE3-negative tumors displayed poorer outcomes regarding progression-free survival than patients with TLE3-positive tumors when prognosis within the group of patients with triple-negative breast cancer (TNBC) lesions was analyzed. In contrast, no such difference in prognosis was found in a comparison of TLE-3 positive/negative patients in the group of all patients. PMID: 28859615
    2. Wnt signaling pathway inactivates the TLE3 co-repressor via HECT E3 ubiquitin ligase Hyd/UBR5 ubiquitination. PMID: 28689657
    3. Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744. PMID: 28107193
    4. Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression PMID: 25249007
    5. induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation PMID: 24444608
    6. High TLE3 expression predicts a favorable response to taxane containing chemotherapy regimens in ovarian carcinoma. PMID: 22194527
    7. A lack of TLE3 expression in cutaneous angiosarcoma may reflect differing pathogenesis. PMID: 22050093
    8. results demonstrate that different isoforms of TLE genes are commonly transcribed in human tissues and suggest that TLE3 could be involved in prostate cancer development PMID: 18273443

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    WD repeat Groucho/TLE family
  • 组织特异性：
    Placenta and lung.
  • 数据库链接：

    HGNC: 11839

    OMIM: 600190

    KEGG: hsa:7090

    STRING: 9606.ENSP00000452871

    UniGene: Hs.287362