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TKFC Antibody

  • 货号：
    CSB-PA659468LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA659468LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA659468LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TKFC Polyclonal antibody
  • Uniprot No.：
    Q3LXA3
  • 基因名：
    TKFC
  • 别名：
    ATP dependent dihydroxyacetone kinase antibody; Bifunctional ATP dependent dihydroxyacetone kinase/FAD AMP lyase (cyclizing) antibody; DAK antibody; DHA kinase antibody; Dha kinase/FMN cyclase antibody; DHAK_HUMAN antibody; Dihydroxyacetone kinase antibody; Dihydroxyacetone kinase 2 antibody; Dihydroxyacetone kinase 2 homolog (S. cerevisiae) antibody; Dihydroxyacetone kinase 2 homolog (yeast) antibody; FAD AMP lyase (cyclic FMN forming) antibody; FAD AMP lyase (cyclizing) antibody; FAD-AMP lyase (cyclic FMN forming) antibody; FAD-AMP lyase (cyclizing) antibody; FMN cyclase antibody; Glycerone kinase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Triokinase/FMN cyclase protein (396-561AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TKFC Antibody (CSB-PA659468LA01HU)，的标记方式是Non-conjugated。对于TKFC Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA659468LB01HU TKFC Antibody, HRP conjugated ELISA
    FITC CSB-PA659468LC01HU TKFC Antibody, FITC conjugated
    Biotin CSB-PA659468LD01HU TKFC Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.
  • 基因功能参考文献：
    1. The peptide fragment (m/z 520.3) of DAK is a promising biomarker to guide timing of antiviral treatment and to avoid liver biopsy in compensated chronic hepatitis B patients. PMID: 24289155
    2. analysis of human triokinase/FMN cyclase reveals that kinase activity requires intact homodimers, but cyclase requires only a truncated, single domain subunit PMID: 24569995
    3. Evidence supports that a single protein sustains both FMN cyclase and ATP-dependent Dha kinase activities, probably in a single active center PMID: 16289032
    4. DAK, the physiological suppressor of cytoplasmic viral RNA sensor MDA5, specifically inhibits MDA5- but not RNA helicase RIG-I-mediated innate antiviral signaling. PMID: 17600090
  • 蛋白家族：
    Dihydroxyacetone kinase (DAK) family
  • 组织特异性：
    Detected in erythrocytes (at protein level).
  • 数据库链接：

    HGNC: 24552

    OMIM: 615844

    KEGG: hsa:26007

    STRING: 9606.ENSP00000378360

    UniGene: Hs.6278