Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. TIPARP Antibody

TIPARP Antibody

  • 货号：
    CSB-PA801800LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: U87 whole cell lysate, SH-SY5Y whole cell lysate
      All lanes: TIPARP antibody at 4.6µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 77 kDa
      Observed band size: 77 kDa
    • IHC image of CSB-PA801800LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA801800LA01HU diluted at 1:300 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品描述：

    Rabbit polyclonal antibody against TIPARP is developed in a rabbit. The peptide sequence for the immunogen was taken from within the amino acids 74-178 of the recombinant human TIPARP protein. This TIPARP antibody is purified by protein G and got a purity of up to 95%. Three applications including ELISA, WB, and IHC have been used in assays to test for the specificity of this TIPARP antibody.

    TIPARP primarily acts as a poly(ADP-ribose) polymerase (PARP) enzyme that is involved in the regulation of DNA repair, chromatin structure, and gene expression. It has also been implicated in the regulation of gene expression, particularly in response to cellular stress and inflammation. TIPARP dysregulation is related to various pathological conditions, including cancer, neurodegenerative diseases, and autoimmune disorders.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TIPARP Polyclonal antibody
  • Uniprot No.：
    Q7Z3E1
  • 基因名：
    TIPARP
  • 别名：
    ADP-ribosyltransferase diphtheria toxin-like 14 antibody; ARTD14 antibody; AW558171 antibody; DDF1 antibody; DKFZp434J214 antibody; DKFZp686N0351 antibody; DKFZp686P1838 antibody; FLJ40466 antibody; PARP 1 antibody; PARP 7 antibody; PARP-7 antibody; PARPT_HUMAN antibody; pART14 antibody; Poly [ADP ribose] polymerase 7 antibody; Poly [ADP-ribose] polymerase 7 antibody; TCDD inducible poly(ADP ribose) polymerase antibody; TCDD-inducible poly [ADP-ribose] polymerase antibody; TIPARP antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human TCDD-inducible poly [ADP-ribose] polymerase protein (74-178AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TIPARP Antibody (CSB-PA801800LA01HU)，的标记方式是Non-conjugated。对于TIPARP Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA801800LB01HU TIPARP Antibody, HRP conjugated ELISA
    FITC CSB-PA801800LC01HU TIPARP Antibody, FITC conjugated
    Biotin CSB-PA801800LD01HU TIPARP Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins. Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR.
  • 基因功能参考文献：
    1. TIPARP is a viral RNA-sensing pattern recognition receptors that mediates antiviral responses triggered by BAX- and BAK1-dependent mitochondrial damage PMID: 28213497
    2. Moreover, time course and promoter activity assays suggest that TIPARP and TIPARP-AS1 work in concert to regulate AHR signaling. Collectively, these data show an added level of complexity in the AHR signaling cascade which involves lncRNAs, whose functions remain poorly understood. PMID: 29274782
    3. Knockdown of TiPARP, but not AHRR, increased 2,3,7,8-tetrachlorodibenzo-p-dioxin - induced CYP1A1 mRNA and AHR protein levels. PMID: 24806346
    4. Single nucleotide polymorphism in TIPARP is associated with ovarian cancer. PMID: 20852632
    5. TIPARP (DKFZp434J214) gene is amplified in HNSCC. TIPARP, FLJ22693 and ZAP proteins with TPH, WW and PARP-like domains constitute the TIPARP family. PMID: 12851707

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 23696

    OMIM: 612480

    KEGG: hsa:25976

    STRING: 9606.ENSP00000295924

    UniGene: Hs.744050