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TIMM50 Antibody

  • 货号：
    CSB-PA674736ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: TIMM50 antibody at 4.05µg/ml
      Lane 1: Rat heart tissue
      Lane 2: MM231 whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Lane 4: Hela whole cell lysate
      Lane 5: 293T whole cell lysate
      Lane 6: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 40, 51, 28 kDa
      Observed band size: 40 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA674736ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA674736ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TIMM50 Polyclonal antibody
  • Uniprot No.：
    Q3ZCQ8
  • 基因名：
    TIMM50
  • 别名：
    TIMM50; TIM50; PRO1512; Mitochondrial import inner membrane translocase subunit TIM50
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Mitochondrial import inner membrane translocase subunit TIM50 protein (87-353AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.; May participate in the release of snRNPs and SMN from the Cajal body.
  • 基因功能参考文献：
    1. Expression of TIM50 was downregulated in hypertrophic hearts. PMID: 28432072
    2. Missense mutations in TIMM50 are likely manifesting by severe intellectual disability and epilepsy accompanied by 3-methylglutaconic aciduria and variable mitochondrial complex V deficiency. PMID: 27573165
    3. TIM50 has a role in regulating cell proliferation and apoptosis through decreasing mitochondrial membrane potential in breast cancer cell PMID: 26289846
    4. the interaction of divalent metal ions with the intermembrane space domain of Tim50 (Tim50(IMS)) and the interaction of presequence peptides with Tim50(IMS) in presence of Ca(2+) ion was investigated. PMID: 23098911
    5. The far-UV CD spectra of Tim50(IMS) in native and denatured states revealed that the protein has a significantly folded secondary structure consisted of alpha-helixes and beta-sheets. PMID: 21742040
    6. Tim50 regulates 3betaHSD2 expression and activity, representing a new role for translocases in steroidogenesis. PMID: 21930695
    7. TIM50, was upregulated in a non-small cell lung carcinoma cell line (H1299) that expressed the p53 mutants R175H and R273H compared to cells lacking p53. PMID: 21621504
    8. Tim50 is important for both mitochondrial function and early neuronal development PMID: 15044455
    9. Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with coilin, snRNPs, and SMN PMID: 16008839

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  • 亚细胞定位：
    Mitochondrion inner membrane; Single-pass membrane protein.; [Isoform 2]: Nucleus speckle.
  • 蛋白家族：
    TIM50 family
  • 组织特异性：
    Widely expressed. Expressed at higher level in brain, kidney and liver (at protein level).
  • 数据库链接：

    HGNC: 23656

    OMIM: 607381

    KEGG: hsa:92609

    STRING: 9606.ENSP00000318115

    UniGene: Hs.590956