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TIAL1 Antibody

  • 中文名称：
    TIAL1兔多克隆抗体
  • 货号：
    CSB-PA023529HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of MCF-7 cells with CSB-PA023529HA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TIAL1 Polyclonal antibody
  • Uniprot No.：
    Q01085
  • 基因名：
    TIAL1
  • 别名：
    Aging associated gene 7 protein antibody; Nucleolysin TIAR antibody; T cluster binding protein antibody; TCBP antibody; TIA 1 related nucleolysin antibody; TIA-1-related protein antibody; TIA1 cytotoxic granule associated RNA binding protein like 1 antibody; TIA1 related protein antibody; TIAL1 antibody; TIAR antibody; TIAR_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Nucleolysin TIAR protein (9-277AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TIAL1 Antibody (CSB-PA023529HA01HU)，的标记方式是Non-conjugated。对于TIAL1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023529HB01HU TIAL1 Antibody, HRP conjugated ELISA
    FITC CSB-PA023529HC01HU TIAL1 Antibody, FITC conjugated
    Biotin CSB-PA023529HD01HU TIAL1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
  • 基因功能参考文献：
    1. we identified MT1JP as a critical factor in restraining cell transformation by modulating p53 translation through interactions with TIAR PMID: 26909858
    2. TIAL1 inhibition of the exon 8 exclusion led to a decrease in SIRT1-Exon8 mRNA levels. PMID: 24566137
    3. A role for TIAR is identified in T-cells for control of translational specificity. PMID: 24927121
    4. findings demonstrate that TIAR recognition motif 2 (RRM2), together with its C-terminal extension, is the major contributor for the high-affinity (nM) interactions of TIAR with target RNA sequences PMID: 23603827
    5. results report the identification of TIAR as a novel player in the regulation of calcitonin/CGRP alternative RNA processing PMID: 12917321
    6. HuR, KSRP and TIAR are bound to one or more loci in the 3'UTR of IL-8 in breast cancer cells. PMID: 15514971
    7. TIAR seems to be involved in the post-transcriptional regulation of human iNOS expression PMID: 16191398
    8. Furthermore, we found that overexpression of DISC1 in SH-SY5Y cells induces the assembly of eIF3- and TIA-1-positive stress granules (SGs), discrete cytoplasmic granules formed in response to environmental stresses. PMID: 16243297
    9. TIAR-mediated inhibition of translation factor expression elicits a sustained repression of protein biosynthesis in cells responding to stress. PMID: 16537914
    10. TIAL1 maintains cytochrome c biosynthesis. PMID: 16581801
    11. adenosine/uridine (AU)-rich element-binding proteins TIA-1 (T-cell intracellular antigen-1), TIAR (TIA-1-related protein), and HuR (Hu antigen R) interact with the beta-F1-ATPase mRNA through an AU-rich sequence located to the 3'-UTR. PMID: 16890199
    12. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. PMID: 17486099
    13. Our in vivo data, taken together with previous in vitro results, show that K-SAM splicing activation involves cooperative binding of TIA-1 and U1 snRNP to the exon's 5' splice site region. PMID: 17512901
    14. Results report the identification of a C-rich signature motif present in TIAR target mRNAs whose association with TIAR decreases following exposure to a stress-causing agent. PMID: 17682065
    15. Show increased TIA-1 positive cytotoxic T-lymphocytes in inflamed mucosa of patients with inflammatory bowel disease. PMID: 17869012
    16. In contrast with previous assumptions, the mutated residues are buried within the hydrophobic interior of the domain, where they would be likely to destabilize the RRM fold rather than directly inhibit RNA binding. PMID: 18201561

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytolytic granule. Cytoplasm, Stress granule.
  • 数据库链接：

    HGNC: 11804

    OMIM: 603413

    KEGG: hsa:7073

    STRING: 9606.ENSP00000358089

    UniGene: Hs.501203