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THRSP Antibody

  • 货号：
    CSB-PA846095ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: THRSPantibody at 2.13μg/ml + K562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 17 kDa
      Observed band size: 17 kDa
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA846095ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA846095ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) THRSP Polyclonal antibody
  • Uniprot No.：
    Q92748
  • 基因名：
    THRSP
  • 别名：
    Lpgp antibody; LPGP1 antibody; MGC21659 antibody; OTTHUMP00000233866 antibody; S14 antibody; S14 protein antibody; SPOT 14 antibody; Spot 14 protein antibody; SPOT14 antibody; SPOT14 homolog antibody; Thrsp antibody; THRSP_HUMAN antibody; Thyroid hormone inducible hepatic protein antibody; Thyroid hormone responsive (SPOT14 homolog rat) antibody; Thyroid hormone responsive antibody; Thyroid hormone responsive protein antibody; Thyroid hormone responsive SPOT14 antibody; Thyroid hormone-inducible hepatic protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Thyroid hormone-inducible hepatic protein (1-146AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.
  • 基因功能参考文献：
    1. The results of the present study indicated that Spot14/S14R were differently expressed in MSC adipogenesis in AIS patients, and they may be important in the abnormal adipogenic differentiation in AIS. PMID: 27082501
    2. In human breast cancer cell lines, S14 expression was highest in those representing the luminal subtype compared to those cell lines with basal characteristics. PMID: 25472762
    3. N-terminally truncated human Thrsp and its selenomethionyl derivative were collected to 4.0, 3.0 and 3.6 A resolution PMID: 21821901
    4. significantly greater thyroid hormone response for the human promoter, compared with the rat. PMID: 12960053
    5. human Spot 14 protein might regulate the p53 target gene, p21(WAF1/Cip1), via its direct interaction with the thyroid receptor or other p53 coactivators, such as Zac1. PMID: 18299245

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    SPOT14 family
  • 组织特异性：
    Mainly expressed in tissues that synthesize triglycerides.
  • 数据库链接：

    HGNC: 11800

    OMIM: 601926

    KEGG: hsa:7069

    STRING: 9606.ENSP00000281030

    UniGene: Hs.591969