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  4. TEX14 Antibody

TEX14 Antibody

  • 中文名称：
    TEX14兔多克隆抗体
  • 货号：
    CSB-PA023405GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8IWB6
  • 基因名：
    TEX14
  • 别名：
    TEX14 antibody; SGK307 antibody; Inactive serine/threonine-protein kinase TEX14 antibody; Protein kinase-like protein SgK307 antibody; Sugen kinase 307 antibody; Testis-expressed sequence 14 antibody; Testis-expressed sequence 14 protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human TEX14
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro.
  • 基因功能参考文献：
    1. Tex14 is an important mediator of kinetochore structure and function and the fidelity of chromosome separation. PMID: 22405274
    2. TEX14 prevents the completion of cytokinesis by altering the destiny of CEP55 from a nidus for abscission to an integral component of the intercellular bridge. PMID: 20176808
    3. TEX14, also known as SgK307, contains a variant and probably inactive protein kinase domain and N-terminal ankyrin repeats. PMID: 12471243
    4. TEX14 is specifically expressed in testis PMID: 11279525
  • 相关疾病：
    Spermatogenic failure 23 (SPGF23)
  • 亚细胞定位：
    Cytoplasm. Midbody. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    Protein kinase superfamily
  • 组织特异性：
    Expression restricted to testis.
  • 数据库链接：

    HGNC: 11737

    OMIM: 605792

    KEGG: hsa:56155

    STRING: 9606.ENSP00000240361

    UniGene: Hs.390221