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TCN1 Antibody

  • 货号：
    CSB-PA023317LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023317LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TCN1 Polyclonal antibody
  • Uniprot No.：
    P20061
  • 基因名：
    TCN1
  • 别名：
    Haptocorin antibody; Haptocorrin antibody; HC antibody; OTTHUMP00000235879 antibody; TC 1 antibody; TC I antibody; TC-1 antibody; TC1 antibody; TCI antibody; TCN 1 antibody; TCN1 antibody; TCO1_HUMAN antibody; Transcobalamin 1 antibody; Transcobalamin I antibody; Transcobalamin-1 antibody; Transcobalamin1 antibody; TranscobalaminI antibody; Vitamin B12 binding protein antibody; Vitamin B12 binding protein R binder family antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcobalamin-1 protein (24-433AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TCN1 Antibody (CSB-PA023317LA01HU)，的标记方式是Non-conjugated。对于TCN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023317LB01HU TCN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA023317LC01HU TCN1 Antibody, FITC conjugated
    Biotin CSB-PA023317LD01HU TCN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
  • 基因功能参考文献：
    1. Higher placental TC protein abundance was associated with higher cord blood vitamin B12 concentrations, suggesting a potential role in vitamin B12 transport to the fetus. PMID: 27577703
    2. The variant rs526934 from the TCN1 gene was associated with an increased risk of developing gastric cancer. PMID: 26959381
    3. Levels of holotranscobalamin are decreased patients with cobalamin deficiency. PMID: 24057896
    4. Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin. PMID: 23846701
    5. TCN1 gene expression implicates disease progression in patient with middle ear cholesteatoma. PMID: 23670528
    6. comparison of human and rainbow trout cobalamin-binding protein PMID: 22872637
    7. Elevated concentrations of B(12) found in autoimmune lymphoproliferative syndrome patients were due to increased lymphocyte expression of haptocorrin. PMID: 22306884
    8. Stromal expression of KRT15, TCN1, and HOXB13 was significantly correlated with tumor grade, stromal hypercellularity, mitotic activity and microscopic borders. PMID: 21574054
    9. two novel mutations, each causing a premature stop codon - a genetic basis for TC I deficiency PMID: 19686235
    10. Comparative analysis of cobalamin binding kinetics PMID: 11788601
    11. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. PMID: 12590948
    12. interactions of COBALAMIN BINDING proteins with a number of ligands PMID: 17487979
    13. Maternal folate-related polymorphisms studied here (CBS, MTR, RFC-1, and TC) have no influence on trisomy 21 susceptibility in subjects of Brazilian population.v PMID: 19729796

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Eukaryotic cobalamin transport proteins family
  • 组织特异性：
    Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
  • 数据库链接：

    HGNC: 11652

    OMIM: 189905

    KEGG: hsa:6947

    STRING: 9606.ENSP00000257264

    UniGene: Hs.2012