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TBXA2R Antibody

  • 货号：
    CSB-PA449379
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA449379(TBXA2R Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P21731
  • 基因名：
  • 别名：
    TBXA2R; Thromboxane A2 receptor; TXA2-R; Prostanoid TP receptor
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide of Human TBXA2R
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C.; Activates adenylyl cyclase.; Inhibits adenylyl cyclase.
  • 基因功能参考文献：
    1. Differential TBXA2 receptor transcript stability is dependent on the C924T polymorphism PMID: 28709878
    2. The tumour suppressors FOXP1 and NKX3.1, strongly implicated in PCa development, were identified as key transcription factors regulating TPbeta expression through Prm3 in both PCa cell lines. PMID: 28890397
    3. The study of patients with naturally occurring variants within TBXA2R associated with bleeding and abnormal TPalpha receptor function has provided a powerful insight in defining the critical role of TPalpha in thrombus formation. PMID: 30089223
    4. these data demonstrate that TPalpha/TPbeta can act as neoplastic and epigenetic regulators by mimicking and/or enhancing the actions of androgens within the prostate and provides further mechanistic insights into the role of the TXA2/TP signalling axis in prostate cancer, including potentially in CRPC. PMID: 28108419
    5. Data show that thromboxane A2 receptor beta-isoform (TPbeta) is highly expressed in intrauterine growth restriction (IUGR) placentae but is absent from healthy placentae. PMID: 27363493
    6. We conclude that hyperglycemia activates thromboxane A2 receptor to impair the integrity and function of blood-brain barrier via the ROCK-PTEN-Akt-eNOS pathway. PMID: 28415790
    7. data presented herein propose a novel diagnostic and prognostic potential for TPalpha and TPbeta in the histopathological assessment of PCa. While TPalpha and TPbeta are differentially expressed and independently regulated, increased levels of TPbeta, TPalpha or both correlated with increased risk of recurrence and reduced disease-free survival time. PMID: 27689401
    8. TBXA2R is a novel breast cancer-associated gene required for the survival and migratory behaviour of a subset of Triple Negative Breast Cancer (TNBC). PMID: 27487152
    9. TXA2R rs1131882TT genotype is associated with carotid plaque vulnerability, platelet activation and TXA2 levels in ischemic stroke patients. PMID: 28704403
    10. We demonstrate that Trp334 in the TPbeta C-terminus is critical for the CCT7 interaction and plays an important role in TPbeta maturation and cell-surface expression. PMID: 27708139
    11. TBXA2R +924C/T polymorphism is associated with asthma risk PMID: 27058349
    12. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. PMID: 27641736
    13. Data suggest that thromboxane A2/TBXA2R signaling promotes multiple myeloma cell proliferation by reducing delay at G2/M phase via up-regulation of MAP kinase pathway, up-regulation of cyclin B1/CDK1 expression, and down-regulation of apoptosis. PMID: 26724804
    14. The results of this study show that TXA2R polymorphisms may affect platelet function and the risk of developing cerebral ischemia. PMID: 25557379
    15. Which could be attenuated by treatment with a TP antagonist (PTXA2). PMID: 25202904
    16. TXA2 receptor associated with lipid rafts in platelets is important for functional platelet responses to TXA2 PMID: 24996187
    17. Data suggest TBXA2R requires Ser324 for normal activity; Ser324A mutant is insensitive to activation by protein kinase A/cell hypoxia, has high affinity for agonists (thromboxane A2/analogs), and participates in agonist-induced calcium mobilization. PMID: 24490858
    18. There was no significant association between rs4523 variants and CI. However, there was a significant difference in the overall distribution of genotypes and dominant/recessive models of rs768963 between CI and control groups PMID: 23456445
    19. TXA2 should be regarded as a critical molecule in COX-2-mediated tumor growth and a valuable target against lung cancer. PMID: 24384873
    20. Human thromboxane A2 receptor genetic variant V80E exhibited reduced platelet activation whereas A160T demonstrated platelet hyperactivity. PMID: 23840660
    21. Targeting the TPalpha-TM5 GxxxGxxxL domain may allow development of biased TPalpha homodimer antagonists that avoid suppression of IP-TPalpha heterodimer function. PMID: 23493750
    22. Non-conservative substitution of E3.49 and E6.30 in prostanoid TP receptor results in superactive mutants that are more efficient in G protein coupling and activation. PMID: 23555978
    23. Genetic variants were identified in the TBXA2R gene that influenced transcriptional activity and were associated with asthma-related phenotypes. PMID: 23517037
    24. In the very rare disorder TP receptor deficiency the W29C substitution reduces TP receptor function by reducing surface receptor expression and by disrupting ligand binding. PMID: 23279270
    25. These results do not support that thromboxane prostanoid receptor activation could exert a moderating influence on reactive hyperemia in human skin and skeletal muscle, at least in young subjects PMID: 23107873
    26. Data show that TXA(2) mimetic, I-BOP, induced monocyte chemoattractant protein -1(MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) expression at both mRNA and protein levels in lung adenocarcinoma A549 cells. PMID: 23349788
    27. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently. PMID: 23255603
    28. IP receptor heteridimerization with thromboxane receptor facilitates receptor trafficking to membrane lipid rafts. PMID: 23162015
    29. Data show that that Ala160(4.53) and Gly164(4.57) in the thromboxane A2 receptor (TP)play critical structural roles in packing of TM3 and TM4 helices. PMID: 22272267
    30. The frequencies of the CC/CT genotype of TBXA2R +795T>C were higher than those of the TT genotype in AERD patients compared to aspirin-tolerant asthma patients. PMID: 22101342
    31. A unique megakaryocytic cell line UT-7/TPO could respond to one of the primary platelet signals through GP (glycoprotein) VI and a secondary signal of the AA (arachidonic acid) cascade. PMID: 20522022
    32. Studies indicate that RAD50 and PTPRE of crude associations with asthma at a Bonferroni-corrected level of significance, while IL4R, CCL5 and TBXA2R of nominal significance. PMID: 21734400
    33. The carboxyl-terminal segment of thromboxane A2 receptor second extracellular loop plays a critical role in platelet activation. PMID: 22008592
    34. TBXA2R-924T allele was involved in AR. Diabetes was an independent risk factor of aspirin resistance. PMID: 21740787
    35. The results suggest that the TBXA2R-4684T allele may be associated with lower TBXA2R expression, which may contribute to the development of the aspirin-intolerant acute urticaria phenotype. PMID: 21070398
    36. the impaired platelet activation in response to U46619 in the heterozygous subject for the TXA(2)R mutation is, at least in part, as a result of the decrease in ADP secretion PMID: 21342433
    37. angio-associated migratory cell protein was identified as a novel interacting partner of both TPalpha and TPbeta isoforms of the thromboxane A2 receptor PMID: 21172430
    38. TBXA2R signaling was regulated by oxidative stress-induced stabilization and relocation. PMID: 20856817
    39. vasoconstrictor TP receptor and MaxiK-channel direct interaction facilitates G-protein-independent TP to MaxiK trans-inhibition, which would promote vasoconstriction. PMID: 20959415
    40. mediates tumor growth and angiogenesis in human lung cancer cells PMID: 19853959
    41. possibility of ligand-free constitutive TBXA2R signaling through Galphaq binding PMID: 20590159
    42. These data establish WT1 as a critical repressor of thromboxane A2 receptor promoter Prm1, suppressing TPalpha expression. PMID: 19067769
    43. D304N substitution causes clinically significant platelet dysfunction by reducing ligand binding establishes the importance of the NPXXY motif for TxA(2)R function in vivo PMID: 19828703
    44. Prostaglandin endoperoxides and thromboxane A2 activate the same receptor isoforms in human platelets. PMID: 11848439
    45. Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. PMID: 11877412
    46. These results suggest TXA2 receptor polymorphism strongly interacts with IL-4R alpha polymorphism as a major determinant of high serum immunoglobulin E levels in atopic dermatitis. PMID: 11922633
    47. The role of TXA2R 5' UTR in differential isoform expression was studied. Exons E1 & E1b associated with TXA2R transcript(s), but their expression was mutually exclusive. Major transcription initiation sites were between -115 & -92 in E1 & at -99 in E1b. PMID: 12180983
    48. Transcriptional activity of the 5'flanking region PMID: 12213432
    49. analysis of third extracellular loop of human thromboxane A2 receptor PMID: 12781781
    50. Thromboxane A2 (TXA2)-mediated platelet secretion and aggregation are important in thrombosis and the stable TXA2 analogue, U46619, induces two waves of platelet secretion, each of which precedes a distinct wave of platelet aggregation PMID: 12796499

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  • 相关疾病：
    Bleeding disorder, platelet-type 13 (BDPLT13)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    HGNC: 11608

    OMIM: 188070

    KEGG: hsa:6915

    STRING: 9606.ENSP00000393333

    UniGene: Hs.442530