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TBC1D20 Antibody

  • 货号：
    CSB-PA846594LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse brain tissue, Mouse stomach tissue
      All lanes: TBC1D20 antibody at 4μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46, 20, 49 kDa
      Observed band size: 46 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA846594LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA846594LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA846594LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate
      All lanes: TBC1D20 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 46, 20, 49 kDa
      Observed band size: 46 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TBC1D20 Polyclonal antibody
  • Uniprot No.：
    Q96BZ9
  • 基因名：
    TBC1D20
  • 别名：
    TBC1D20; C20orf140; TBC1 domain family member 20
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human TBC1 domain family member 20 protein (1-237AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TBC1D20 Antibody (CSB-PA846594LA01HU)，的标记方式是Non-conjugated。对于TBC1D20 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA846594LB01HU TBC1D20 Antibody, HRP conjugated ELISA
    FITC CSB-PA846594LC01HU TBC1D20 Antibody, FITC conjugated
    Biotin CSB-PA846594LD01HU TBC1D20 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude.
  • 基因功能参考文献：
    1. Warburg Micro syndrome is caused by TBC1D20 deficiency. PMID: 26063829
    2. Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans. PMID: 24239381
    3. The NS5A interaction with TBC1D20 and Rab1 is essential for the viral life cycle. PMID: 22491470
    4. These findings add TBC1D20 to the network of host factors regulating HIV replication cycle. PMID: 22260459
    5. TBC1D20 was found to be the first known GAP for Rab1, which is implicated in the regulation of anterograde traffic between the endoplasmic reticulum and the Golgi complex PMID: 17901050

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  • 相关疾病：
    Warburg micro syndrome 4 (WARBM4)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 数据库链接：

    HGNC: 16133

    OMIM: 611663

    KEGG: hsa:128637

    STRING: 9606.ENSP00000346139

    UniGene: Hs.590876