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TAS2R1 Antibody

  • 货号：
    CSB-PA020241
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9NYW7
  • 基因名：
  • 别名：
    TAS2R1; Taste receptor type 2 member 1; T2R1; Taste receptor family B member 7; TRB7
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human T2R1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
  • 基因功能参考文献：
    1. TAS2R agonists block signaling downstream of phosphatidylinositol 3-kinase PMID: 26684251
    2. Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes PMID: 25573083
    3. Intracellular signaling and cell mechanics using isolated human airway smooth muscle, mouse tracheal responses, and human bronchial responses to characterize TAS2R relaxation in the context of beta(2)AR desensitization. PMID: 22683571
    4. The formation of a short helical segment in intracellular loop II may be necessary for the activation of hTAS2R1. PMID: 21619450
    5. Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs). PMID: 21852241
    6. The ligand binding pocket in T2R1 is present on the extracellular surface of the receptor, and is formed by the transmembrane helices 1, 2, 3 and 7 and with extracellular loops 1 and 2 forming a cap like structure on the binding pocket. PMID: 20599705

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor T2R family
  • 组织特异性：
    Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.
  • 数据库链接：

    HGNC: 14909

    OMIM: 604796

    KEGG: hsa:50834

    STRING: 9606.ENSP00000371932

    UniGene: Hs.567492