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TAS1R3 Antibody

  • 货号：
    CSB-PA060280
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q7RTX0
  • 基因名：
  • 别名：
    G protein coupled receptor antibody; Sac antibody; Saccharin preference antibody; Sweet taste receptor T1R3 antibody; T1 R3 antibody; T1R 3 antibody; T1R3 antibody; TAS1 R3 antibody; TAS1R 3 antibody; TAS1R3 antibody; Taste receptor type 1 member 3 antibody; Taste receptor type 1 member 3 precursor antibody; TR 3 antibody; TR3 antibody; TS1R3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human T1R3.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.
  • 基因功能参考文献：
    1. Regarding "consumption of carbohydrates (% energy) and higher amount of sweet foods, respectively...no associations were found for the TAS1R3 alleles." PMID: 29110749
    2. TAS1R3 gene rs307355 polymorphism found independent risk factor for dental caries experience by logistic regression & increased risk of caries. Moderate caries (4-7 caries) found to be associated w/TAS1R3 rs307355 heterozygous genotype PMID: 25924601
    3. T1R3 gene expression in the tongue is suppressed by chemotherapy. PMID: 26422579
    4. The transcripts of TAS1R3 and UCN2 in peripheral blood cells may be considered potential biomarkers of consumption of sugary and fatty food, respectively, to complement data of food-intake questionnaires. PMID: 26168276
    5. Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin PMID: 23370115
    6. T1R3 is a receptor responsible for the detection of calcium by taste. PMID: 22773945
    7. Overexpressed the human N-terminal domain of T1R3 in E. coli and found that the refolded protein behaves as a dimer; showed that hT1R3-NTD is functional and capable of binding sucralose with an affinity in the millimolar range. PMID: 22450161
    8. amino acid substitutions (F749S and R757C), located in the transmembrane domain of T1R3, severely impair receptor functions in vitro PMID: 21422378
    9. The sweet taste receptors (alpha-gustducin and T1R3) are involved in glucose-stimulated secretion of GLP-1 and PYY. PMID: 21324568
    10. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. PMID: 19559618
    11. The mechanism of interaction of the sweet protein monellin with T1R2-T1R3 receptor. PMID: 12706725
    12. cysteine-rich region of T1R3 has a role in determining responses to intensely sweet proteins PMID: 15299024
    13. An immunohistochemistry study to determine whether and where T1R3 may be localized in the liver and pancreas. PMID: 15585941
    14. transmembrane domains of human T1R3 bind with lactisole to inhibit sweet taste PMID: 15668251
    15. Although T1R2-T1R3 is known to have multiple potential ligand-binding sites to receive a wide variety of sweeteners, the present study is apparently the first to identify the ATD of hT1R3 as a new sweetener-binding region. PMID: 17499612
    16. These results show that T1R2 and T1R3 receptors, in addition to their role in taste perception, may also have a role in intrahepatic cholangiocytes. PMID: 17928076
    17. Expressed in the sweet/umami gustatory pathways in taste receptor cells and trigeminal neural pathways in transgenic mice. PMID: 18539481
    18. The heteromeric G-protein-coupled receptor T1R2:T1R3 responds to a vast array of chemically diverse natural and artificial sweeteners. PMID: 19083128
    19. Variations in perception of umami taste correlated with variations in the human TAS1R3 gene. PMID: 19587085

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family, TAS1R subfamily
  • 数据库链接：

    HGNC: 15661

    OMIM: 605865

    KEGG: hsa:83756

    STRING: 9606.ENSP00000344411

    UniGene: Hs.74375