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TAP2 Antibody

  • 货号：
    CSB-PA088613
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA088613(TAP2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q03519
  • 基因名：
  • 别名：
    ABC transporter, MHC 2 antibody; ABC18 antibody; ABCB3 antibody; Antigen peptide transporter 2 antibody; APT2 antibody; ATP binding cassette, sub family B (MDR/TAP), member 3 antibody; ATP-binding cassette sub-family B member 3 antibody; D6S217E antibody; Peptide supply factor 2 antibody; Peptide transporter involved in antigen processing 2 antibody; Peptide transporter PSF2 antibody; Peptide transporter TAP2 antibody; PSF 2 antibody; PSF-2 antibody; PSF2 antibody; Really interesting new gene 11 protein antibody; RING 11 antibody; RING11 antibody; TAP 2 antibody; Tap2 antibody; TAP2_HUMAN antibody; Transporter 2 ATP binding cassette sub family B antibody; Transporter 2, ABC (ATP binding cassette antibody; Transporter 2, ATP binding cassette, sub family B (MDR/TAP) antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human TAP2
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ABC transporter associated with antigen processing. In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules. Uses the chemical energy of ATP to export peptides against the concentration gradient. During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle. Typically transports intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome. Binds peptides with free N- and C-termini, the first three and the C-terminal residues being critical. Preferentially selects peptides having a highly hydrophobic residue at position 3 and hydrophobic or charged residues at the C-terminal anchor. Proline at position 2 has the most destabilizing effect. As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation.
  • 基因功能参考文献：
    1. Our findings support the hypothesis that hsa-miR-1270 suppresses the production of TAP2 by binding to this SNP in the 3'-UTR of this gene PMID: 29205500
    2. The present study illustrated that the carriage of LMP7 rs2071543-AA and TAP2 rs1800454-AA had a negative effect on treatment response to pegIFN-alpha/RBV among genotype 1 patient with chronic hepatitis C (CHC) in a Chinese Han population PMID: 29039469
    3. We replicated the association between the rs2071473 genotype and TAP2 expression by using GTEx data and demonstrated that TAP2 is expressed by decidual stromal cells at the maternal-fetal interface. PMID: 27745831
    4. Two eSNPs were associated with fecundability at a FDR of 5%; both were in the HLA region and were eQTLs for the TAP2 gene (P = 1.3x10-4) and the HLA-F gene (P = 4.0x10-4), respectively. PMID: 27447835
    5. These results suggest that TAP2 polymorphisms influence TB susceptibility in a Japanese population. PMID: 27325005
    6. Deletions of ABCB3 predict good tumor response to neoadjuvant chemotherapy in breast cancer. PMID: 26799285
    7. TAP/TPN complex formation is driven by hydrophobic interactions via leucine zipper-like motifs. PMID: 26519531
    8. TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population PMID: 25874709
    9. We showed that TAP2 gene has an association with pulmonary tuberculosis in Koreans. PMID: 25846714
    10. Our meta-analyses suggested that TAP2-379Ile allele was significantly associated with a 59% increased risk for rheumatoid arthritis PMID: 24972609
    11. Results suggested an association between TAP2-565 polymorphism and chronic lymphoid leukemia (CLL). TAP2-665 GG genotype might be a risk factor for CLL, chronic myeloblastic leukemia, and multiple myeloma. PMID: 24175803
    12. Three tapasin binding sites on TAP have been described, two of which are located in the N-terminal domains of TAP1 and TAP2. PMID: 24501197
    13. Although lung cancer cells bearing the preprocalcitonin ppCT(16-25) epitope display low levels of TAP, restoration of TAP expression inhibits ppCT antigen presentation. PMID: 23302073
    14. the N-terminal region of Snm1B forms a complex containing PSF2 and Mus81, while the C-terminal region is important for PSF2-mediated chromatin association. PMID: 23189151
    15. Genetic variation in TAP2 was associated with NHL risk overall, and follicular lymphoma risk in particular, and this was independent of other established loci from 6p21.3. PMID: 22911334
    16. the N-terminal extension of the TAP2 subunit represents an autonomous domain, which is correctly targeted to and inserted into the endoplasmic reticulum membrane PMID: 22638925
    17. Comparison of unpaired 50 primary breast cancer and 33 brain metastases showed lower expression of beta2-microglobulin, transporter associated with antigen processing (TAP) 1, TAP2 and calnexin in the brain lesions. PMID: 22065046
    18. Regression analysis revealed that polymorphisms and haplotypes of TAP2 were associated with FEV1 decline by aspirin provocation (P=0.002-0.04) in most of minor homozygotes compared with major homozygotes and AERD development. PMID: 21796142
    19. genetic polymorphism is associated with end stage renal disease in patients of North India PMID: 21440064
    20. Single cysteine residue within the antigen translocation complex TAP controls the epitope repertoire by stabilizing a receptive conformation. PMID: 20439763
    21. The higher frequency of HLA class I antigen and TAP down-regulation in metastases play a role in the clinical course of the disease. PMID: 20204276
    22. TAP-impaired HLA class I expression could influence the course of SCC originating in chronic ulcers and could be related to escape from cytotoxic T-lymphocyte surveillance during disease progression. PMID: 20083708
    23. Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes. PMID: 11916171
    24. There was a significant difference in the frequencies at position 665 of TAP 2 gene. TAP genes might have modifying effects on the cystic fibrosis phenotype. PMID: 12026214
    25. TAP2*Bky2 or its haplotype with DRB1*08032 may be involved in SS-A/Ro antibody production not only in SS but also SLE, indicating that TAP2*Bky2 may be a susceptible gene not only to the disease of SS but also to the SS-A/Ro autoantibody production. PMID: 12729048
    26. Expression of TAP2 is not identical to TAP1 in primary melanoma lesions. PMID: 12777979
    27. this allele is preferentially associated with the large conserved haplotype HLA DQA1*0501-DQB1*0201-DRB1*0301 and restricted to populations of African origin PMID: 12786999
    28. detected the presence of 17 nucleotide sequence variations in the entire coding region of TAP2 in an indigenous Zimbabwean population (Shona ethnic group) PMID: 12826376
    29. TAP2 gene polymorphism is not linked to renal cell carcinoma PMID: 12963978
    30. The results of this study provide genetic evidence that TAP2 gene codon 565 polymorphism may play a role in rheumatoid arthritis. PMID: 14749980
    31. Evidence is provided that that the extended haplotype of TAP2 is distinct in pauciarticular and polyarticular rheumatoid factor negative juvenile idiopathic arthritis patients. PMID: 15343265
    32. TAP1-2 gene polymorphisms may, by way of post-transcriptional changes and altered regulation of gene expression, be involve the immune system in the development of primary open-angle glaucoma PMID: 15887980
    33. Transmembrane segment 1 (TM1) of core-TAP2 is critical for its heterodimerization with core-TAP1. PMID: 16061226
    34. Results suggest the possible role of TAP2 gene polymorphism in the genetic susceptibility to systemic sclerosis . PMID: 16112028
    35. TAP variants lacking TAP2 N-terminal domain build peptide-loading complexes (PLC) that fail to generate stable MHC I-peptide complexes, which correlates with a substantially reduced recruitment of accessory chaperones into the PLC PMID: 16210614
    36. The TAP2-2 MspI polymorphism might be associated with calcium stone disease. PMID: 16215317
    37. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the APOE4 allele. PMID: 16595160
    38. Two Pemphigus vulgaris (PV) TAP2 risk alleles were identified (TAP2*C and TAP2*D) implying that TAP2 genes are involved in susceptibility to development of PV. PMID: 16690408
    39. These data reveal that the single-site polymorphism of the TAP2 gene at codon 665 may be an indicator for predicting Graves Disease development. PMID: 16721835
    40. The main active site required for peptide translocation by TAP1-TAP2 complexes resides at the TAP2 nucleotide binding site. PMID: 17068338
    41. Evidence of TAP2 association with type 1 diabetes that is independent of HLA DR-DQ may be based on allele dependence of splicing into isoforms known to have differential peptide selectivities. PMID: 17192492
    42. TAP2-651 site is associated with the risk of HBV infection PMID: 17525827
    43. First report on the role of TAP2 polymorphisms involved in the diverse pathogenesis of dengue virus infection. PMID: 18071882
    44. Allele 665 is associated with cervical cancer, but this is strongly influenced by linkage disequilibrium with human leukocyte antigen DQB1. PMID: 18650831
    45. Downregulation of TAP2 is associated with acute myeloid leukaemic blasts. PMID: 19148137

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  • 相关疾病：
    Bare lymphocyte syndrome 1 (BLS1)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments seem to form a pore in the membrane.
  • 蛋白家族：
    ABC transporter superfamily, ABCB family, MHC peptide exporter (TC 3.A.1.209) subfamily
  • 数据库链接：

    HGNC: 44

    OMIM: 170261

    KEGG: hsa:6891

    STRING: 9606.ENSP00000364034

    UniGene: Hs.502