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TAF6L Antibody

  • 货号：
    CSB-PA003697
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using PAF65α Polyclonal Antibody
    • Western Blot analysis of various cells using PAF65α Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9Y6J9
  • 基因名：
    TAF6L
  • 别名：
    TAF6L antibody; PAF65A antibody; TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L antibody; TAF6L antibody; PCAF-associated factor 65-alpha antibody; PAF65-alpha antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human PAF65α.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state. Functions with MYC to activate target gene expression through RNA polymerase II pause release.
  • 基因功能参考文献：
    1. immunohistochemical studies suggest that CBP, depending on the balance of nuclear proteins, is a component of AIRE nuclear bodies PMID: 15964547
    2. protein kinase C betaII augments NF-kappaB-mediated TNF-alpha-induced transcription of the target gene CCL11, promoting p65 association with the CCL11 promoter, in human airway smooth muscle cells by phosphorylating p300/CBP-associated factor PMID: 18714023
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TAF6 family
  • 数据库链接：

    HGNC: 17305

    OMIM: 602946

    KEGG: hsa:10629

    STRING: 9606.ENSP00000294168

    UniGene: Hs.714400