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TAF6 Antibody

  • 货号：
    CSB-PA023095LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA023095LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TAF6 Polyclonal antibody
  • Uniprot No.：
    P49848
  • 基因名：
    TAF6
  • 别名：
    TAF6 antibody; TAF2E antibody; TAFII70 antibody; Transcription initiation factor TFIID subunit 6 antibody; RNA polymerase II TBP-associated factor subunit E antibody; Transcription initiation factor TFIID 70 kDa subunit antibody; TAF(II)70 antibody; TAFII-70 antibody; TAFII70 antibody; Transcription initiation factor TFIID 80 kDa subunit antibody; TAF(II)80 antibody; TAFII-80 antibody; TAFII80 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Transcription initiation factor TFIID subunit 6 protein (627-677AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，TAF6 Antibody (CSB-PA023095LA01HU)，的标记方式是Non-conjugated。对于TAF6 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA023095LB01HU TAF6 Antibody, HRP conjugated ELISA
    FITC CSB-PA023095LC01HU TAF6 Antibody, FITC conjugated
    Biotin CSB-PA023095LD01HU TAF6 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.; Transcriptional regulator which acts primarily as a positive regulator of transcription. Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis. Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1. In contrast, down-regulates transcription of MDM2. Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1. Can also activate transcription and apoptosis independently of TP53. Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA.
  • 基因功能参考文献：
    1. data point to several new RNA elements that can modulate TAF6delta and also reveal a role for RNA secondary structure in the selection of TAF6delta PMID: 25025302
    2. The transcriptome data uncovered novel links between TAF6delta expression and the Notch, oxidative stress response, integrin, p53, p53 feedback loop 2, and angiogenesis pathways. PMID: 20096117
    3. a novel protein-protein interaction was observed between TAFII70 (not TAFII80) and GADD45a PMID: 15328371
    4. TAF6delta has a pivotal node in a signaling pathway that controls gene expression programs and apoptosis in the absence of p53 PMID: 18628956
  • 相关疾病：
    Alazami-Yuan syndrome (ALYUS)
  • 亚细胞定位：
    Nucleus.; [Isoform 4]: Nucleus.
  • 蛋白家族：
    TAF6 family
  • 数据库链接：

    HGNC: 11540

    OMIM: 602955

    KEGG: hsa:6878

    STRING: 9606.ENSP00000399982

    UniGene: Hs.489309