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TAF1C Antibody

  • 货号：
    CSB-PA620884ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA620884ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA620884ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA620884ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) TAF1C Polyclonal antibody
  • Uniprot No.：
    Q15572
  • 基因名：
    TAF1C
  • 别名：
    RNA polymerase I-specific TBP-associated factor 110 kDa antibody; SL1 antibody; Taf1c antibody; TAF1C_HUMAN antibody; TAFI110 antibody; TAFI95 antibody; TATA box binding protein associated factor 1C antibody; TATA box-binding protein-associated factor 1C antibody; TATA box-binding protein-associated factor RNA polymerase I subunit C antibody; TBP associated factor 1C antibody; TBP associated factor RNA polymerase I 95 kDa antibody; TBP associated factor; RNA polymerase I; 110-KD antibody; TBP-associated factor 1C antibody; Transcription initiation factor SL1/TIF-IB subunit C antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human TATA box-binding protein-associated factor RNA polymerase I subunit C protein (70-320AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
  • 基因功能参考文献：
    1. Our results indicate that TAF1C gene harboured not only somatic frameshift mutations but also the mutational ITH, which together might play a role in tumourigenesis of gastric and colorectal cancer. PMID: 25551296
    2. PTEN represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 complex PMID: 16055704
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 11534

    OMIM: 604905

    KEGG: hsa:9013

    STRING: 9606.ENSP00000367802

    UniGene: Hs.153022