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TAF12 Antibody

  • 货号：
    CSB-PA995016
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA995016(TAF12 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA995016(TAF12 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q16514
  • 基因名：
    TAF12
  • 别名：
    TAF12 antibody; TAF12 RNA polymerase II; TATA box binding protein (TBP)-associated factor; 20kDa antibody; TAF12_HUMAN antibody; TAF15 antibody; TAF2J antibody; TAFII 20/TAFII 15 antibody; TAFII-20/TAFII-15 antibody; TAFII20 antibody; TAFII20/TAFII15 antibody; Transcription initiation factor TFIID 20/15 kDa subunits antibody; Transcription initiation factor TFIID subunit 12 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human TAF12
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.
  • 基因功能参考文献：
    1. Ectopic expression of the TAF4 histone-fold fragment can efficiently squelch TAF12 in cells PMID: 29316427
    2. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12, an RNA polymerase II TATA-box binding factor, cause CIN when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1 PMID: 27551064
    3. TAF12 and NFYC are transcription factors that regulate the epigenome, whereas RAD54L plays a central role in DNA repair PMID: 25965574
    4. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD. PMID: 23426901
    5. TAF12 hitherto regarded as RNA polymerase II (RNAP II)-specific was found to be also involved in RNAP I transcription. PMID: 17268553

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TAF12 family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 11545

    OMIM: 600773

    KEGG: hsa:6883

    STRING: 9606.ENSP00000263974

    UniGene: Hs.530251