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TADA3 Antibody

  • 货号：
    CSB-PA023075GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O75528
  • 基因名：
    TADA3
  • 别名：
    TADA3 antibody; ADA3 antibody; TADA3L antibody; Transcriptional adapter 3 antibody; ADA3 homolog antibody; hADA3 antibody; STAF54 antibody; Transcriptional adapter 3-like antibody; ADA3-like protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human TADA3L
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
  • 基因功能参考文献：
    1. These results reveal a novel RTK-AKT-p300-ADA3 signaling pathway involved in growth factor-induced cell cycle progression. PMID: 28759294
    2. PCAF and ADA3 transcriptionally regulate PACS1 and PACS1 is a key regulator of BAX/BAK oligomerization and the intrinsic (mitochondrial) pathway to apoptosis. PMID: 28060382
    3. ADA3 overexpression enhances cell proliferation that is associated with increased expression of c-MYC. Expression patterns with respect to ADA3/c-MYC can divide patients into four significantly different subgroups, with c-MYC High and ADA3 Low status independently predicting poor survival in patients. PMID: 27852327
    4. review on hADA3 with a comprehensive outlook on the molecular and functional roles of hADA3 PMID: 27605378
    5. Findings demonstrate that acetylation of ADA3 by its associated histone acetyltransferases is essential for its key role in histone acetylation and cell cycle progression. PMID: 27402865
    6. results thus demonstrate that the catalytic activity of GCN5 is stimulated by subunits of the ADA2a- or ADA2b-containing HAT modules and is further increased by incorporation of the distinct HAT modules in the ATAC or SAGA holo-complexes PMID: 26468280
    7. PCAF and ADA3 regulate Bid processing via PACS2, to modulate the mitochondrial cell death pathway in response to hGrzB. PMID: 24464226
    8. Cytoplasmic localization of alteration/deficiency in activation 3 (ADA3) predicts poor clinical outcome in breast cancer patients. PMID: 23288344
    9. Expression of the interacting proteins altered expression of an hADA3-regulated reporter gene, suggesting functional consequences for the interactions. PMID: 23167988
    10. a critical role of Ada3 in embryogenesis and cell cycle progression as an essential component of HAT complex. PMID: 22736770
    11. hADA3 interacts directly with RARalpha in a hormone-dependent manner and this interaction contributes to RARalpha transactivation PMID: 20413580
    12. Data identify hADA3, human homologue of the yeast transcriptional coactivator yADA3, as a novel human papillomavirus oncoprotein E6-interacting protein and a target of E6-induced degradation. PMID: 12138191
    13. Results demonstrate that human papilloma virus 16 E6 oncoprotein inhibits the RXR(alpha)-mediated transactivation of target genes, implying that perturbation of RXR-mediated transactivation by E6 could contribute to HPV oncogenesis. PMID: 12235159
    14. results demonstrate that transcriptional adaptor ADA3 protein directly binds to human estrogen receptor alpha and beta and enhances the transcription of estrogen receptor-responsive genes PMID: 15496419
    15. human Ada3 has an essential role in p53 acetylation PMID: 17272277
    16. p14ARF signals through hAda3 to stimulate p53 acetylation and the induction of cell senescence PMID: 17452980
    17. hADA2a and hADA3 as crucial cofactors of beta-catenin that are likely involved in the assembly of transactivation-competent beta-catenin complexes at Wnt target genes. PMID: 18059173
    18. Role of Ada3 in histone acetyltransferase recruitment to estrogen-responsive target gene promoters and for estrogen-dependent proliferation of breast cancer cells. PMID: 18089809
    19. The findings strongly imply that the inactivation of the p14ARF-p53 pathway, either by the E6-mediated degradation of p53 or hAda3 or by cellular adaptation, is required for MEC immortalization. PMID: 18256148
    20. ADA3 is a newly identified target of the ANCO proteins, which may modulate co-activator function in a transcription-factor-specific manner PMID: 18377363
    21. oncoprotein E6 inhibits hADA3 in cervical cancer cells and this process is E6AP-dependent. PMID: 19194825

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    NGG1 family
  • 组织特异性：
    Ubiquitously expressed.
  • 数据库链接：

    HGNC: 19422

    OMIM: 602945

    KEGG: hsa:10474

    STRING: 9606.ENSP00000307684

    UniGene: Hs.386390